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The clonotypes of CD8+ T cells specific to 9 SARS-CoV-2 epitopes are identified from COVID-19 convalescent patients and the longitudinal study of these clonotypes reveals that T cell persistence correlates with TCR diversity.
Crystallographic and biochemical characterization of Leishmania donovani Glucose 6-Phosphate Dehydrogenase (LdG6PD) containing the complete N-terminal domain reveal its role in LdG6PD tetramerization and substrate binding.
Analysis of fMRI recordings from an autobiographical memory recall tasks suggests that neural activation during emotional experiences can be better predicted by psychological construction theory, rather than classic basic emotions theory.
The MetE like complex is found to be capable of regulating the PKS system to produce EPA in Schizochytrium, with its activation regulating the expression of key enzymes, improving the efficiency of DHA and EPA production.
A cognitive brain machine interface that continuously tracks momentary changes in electrophysiological steady-state visually evoked potentials (SSVEPs) in real-time provides a reliable readout of attentional state in humans.
A genome-wide evaluation in four different dog breeds identifies multiple genomic regions that were significantly related to risk of atopic dermatitis, providing additional biological insights into disease pathogenesis in dogs.
Functionalization of a macroporous elastic-like recombinamer hydrogel with synthetic glycosaminoglycans enables controlled binding and release of growth factors for blood vessel formation with reduced immune response in a subcutaneous mouse model.
Fluorescence lifetime imaging microscopy combined with phasor analysis resolves seeding and aggregation dynamics of different α-synuclein polymorphs in a biosensor cell line.
Integration of functional, structural, and neurochemical data proposes a framework to comprehensively understand the neural basis of attention across different species and neurological diseases.
A probiotic bacterial strain (Lacticaseibacillus rhamnosus) delays neurodegeneration phenotypes in C. elegans models of amyotrophic lateral sclerosis and Huntington’s disease, with fatty acid extracts from the bacteria able to reproduce the protective effect.
By identifying circ-CREBBP out of differently expressed circRNAs in seminal plasma extracellular vesicles from boars with high and low sperm motility, the circRNA is shown to play a role in sperm survival and apoptosis.
Computationally parallel ‘change-of-mind’ tasks in mice, rats and humans are analysed and demonstrate that sensitivity to sunk costs during re-evaluation depends on the awareness of time spent and remaining.
Protein crystal growth experiments in a microgravity environment provide insight into the design of an engineered direct electron transfer type glucose dehydrogenase with increase thermal stability for glucose sensor applications.
The mating type determining gene, MID, in Chlamydomonas reinhardtii algae governs formation of the α and β mating structures, highlighting a potential genetic basis for mating type- or sex-specific asymmetric positioning of the chlorophyte mating structure.
The BRCC36 isopeptidase complex (BRISC) is identified as the deubiquitinating enzyme for Lys63-linked ubiquitination of Aurora B, and hyperactivated Aurora B in the absence of BRISC leads to erroneous chromosome–microtubule attachment during mitosis.
KLF4-induced phenotypic switching of vascular smooth muscle cells occurs in atherosclerosis. Now, KLF4 is shown to induce a glycolytic shift involving upregulation of PFKFB3 expression through circular RNA CTDP1 and eukaryotic elongation factor eEF1A2.
The SMART (MLKL-activation reporter) system FRET biosensor allows for necroptosis assessment in primary cells and in a mouse model of cisplatininduced AKI.