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The bacterial T3SS effector YfiD interacts with the catalytic domain of host PARP1 during infection. Inhibition of PARP1 activity impairs the pro-inflammatory response against bacterial infection.
A protein-agnostic bioinformatic tool is capable of predicting transcription factor:DNA interactions, facilitating genome mining for chemical-inducible synthetic biology sensors.
Physiological and molecular studies have shown that 3,4-dichlorophenylacetic acid (Dcaa) has auxin-like activity and acts through the auxin signaling pathway in plants. This provides a basis for the application of Dcaa in agricultural practice.
Synchrotron X-ray imaging of stimulated human middle ears reveals the 3D movement of auditory ossicles: it enables their motion quantification, confirms the lever-like motions of the malleus and incus and reveals a more intricate stapedial behavior.
This study reports RNA recognition by hMEX3B via NMR, SAXS and MD simulation methods. The authors also investigated hMEX3B functions both in vitro and in vivo and proposed how hMEX3B promotes tumor immune escape by regulating the HLA-A.
A single-cell RNA sequencing study about POP constructed a transcriptional profile of 30,452 single cells of the uterosacral ligament in human for the first time, revealing a picture of immune cell infiltration in USL tissue of POP samples.
The anatomy of the Drosophila female lower reproductive tract is probed using a combination of high-resolution correlative three-dimensional imaging techniques, highlighting aspects of seminal receptacle sperm interactions and sperm viability.
Cells stretch to thin films through the use of a nanostructured membrane. Analysis of the thin film interference colors of the stretched cells allows simultaneous measurement of the specimens’ pointwise thickness and refractive index.
Microspray, nano-imaging and chemical analysis reveal time-dependent changes in the structural properties of amyloid fibrils in their plateau phase, conferring changes on the fibril surfaces for secondary nucleation and catalysis of aggregation.
TMEM16A acts in smooth muscle cells as a critical pacemaker channel that enables the internal anal sphincter to contract rhythmically and continuously, a critical phenomenon to allow for fecal continence.
Combined transcriptomics and proteomics of skin and lymphoid organs reveal the significance of SPINK5 in the regulation of protease activity and systemic inflammation, providing a conserved molecular framework for Netherton syndrome.
Single-molecule DNA manipulations experiments reveal that the TRF2 component of the telomeric-specific complex exhibits multiple DNA-binding modes on telomeric DNA that can switch between extended and compact conformations with no strong preference for DNA supercoiling chirality under tension.
The authors use phage display to develop dual-specific single-chain variable fragments against DNA and N-pyrrolated proteins, providing mechanistic insights into the multi-specificity of anti-DNA antibodies.
A stable isotope study elucidated a nutrient recycling pathway in which the coral holobiont incorporates nutrients from sponge-derived matter and interspecific differences in incorporation align with ecophysiological characteristics of the coral.
Small and large-scale movements are observed in the dark-adapted state of a photoactivated adenylate cyclase from the cyanobacterium Oscillatoria acuminata upon ATP binding using fluorescence and solution X-ray scattering methods.
An fMRI study suggests that epilepsy-related perturbations of spontaneous brain activity affect macroscale intrinsic dynamics and microcircuit organizations, and that they are highly spatially correlated.
An assay-based laboratory study that defines precompetency durations of 2 – 6 days and compares settlement preference amongst common inducers, for 25 Scleractinian Indo-Pacific coral species.
A new restoration approach reveals that planting ‘Reef Carpets’ instantly generates ecological habitats for coral-associated organisms and supports coral recruitment, providing an innovative tool to scaleup reef restoration and biodiversity benefits.
An interaction between hepatocyte nuclear factor 4A (HNF4A) and the MLL4 complex is important for histone modifications at cis regulatory regions to alter gene expression in vivo and in vitro.