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A computational framework can extract spatio-spectro-temporal neural signatures corresponding to hierarchical prediction and prediction errors in a local-global auditory task.
Sequencing data on two Hawai’i isolates and other SARS-CoV-2 variants, their lineages, amino acid substitutions, and monthly prevalence are evaluated in a rule-based algorithm to monitor and determine virus evolution and emergence for vaccine design.
Complementary multi-omics approach, in silico metabolic flux, and neuroimaging analyses link the sphingolipid pathway to Alzheimer’s disease pathogenesis with therapeutic targets validated using behavioral assessments in amyloidogenic APP/PS1 mice.
Soil microbiota, including arbuscular mycorrhizal fungi (AMF), are critical for plant nutrition in non-agricultural ecosystems. A new study by Edlinger et al. shows that agricultural soils are negatively impacted by fungicide use and generally have lower AMF diversity and abundance.
More than twenty years have passed since the first complex genetic circuits were implemented in the model bacteria, Escherichia coli. Yet, translating these circuits to other clinically-relevant bacteria remains a challenge. In a recent study, Huang and colleagues applied engineered transcription factors to control the growth of a microbial community of Bacteroides species.
The high-speed single-molecule miRNA detection technique dynamic FRET-FISH shows increased detection speed and high target specificity, detecting a single miRNA in ten seconds.
Integrating cellular microarrays, experimental and computational data for liver progenitor cell differentiation patterning, the interplay between Notch signaling and cellular mechanics is assessed.
Notch signaling promotes the quiescent state of endometrial mesenchymal stromal/stem cells (eMSC), whose re-rentry into the cell cycle is in turn influenced by Notch and Wnt signaling from the microenvironment.
Comprehensive profiling of ligand-induced perturbation responses of the MCF10A mammary epithelial cell line provides an exhaustive resource for identification of the molecular basis of cellular phenotypes.
Fluorescence proximity sensing enables high throughput determination of binding affinities and kinetics of peptide inhibitors with varying valency and multivalent architecture.
A competitive efflux assay combined with computational approaches reveal how different quinolones interact with the prototypical bacterial multidrug efflux transporter AcrB, providing insights which may help optimise antibiotics.
SoloTE includes the genome location of transposable elements (TE) in scRNA-Seq data to determine how TE activity regulates neighboring gene expression.
The risk of germline copy number variants (CNVs) in BRCA1 and BRCA2 pathogenic variant carriers in breast cancer is assessed, with CNVs overlapping SULT1A1 decreasing breast cancer risk in BRCA1 carriers.
Muscular pathologies, including muscular dystrophy, are caused by a number of cellular and metabolic perturbations; here, consequences of GRPEL1-null disrupted mitochondrial matrix protein import on muscle atrophy, metabolism, and stress responses are examined.
The translocation of cephalosporins across enterobacterial OmpF and OmpC channels is monitored in real-time, demonstrating differential permeation of some cephalosporins through OmpF and OmpC.