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This study identifies a unique “internal-PDZ binding motif” (IPM) of WGEF that mediates its interaction with Dvl2PDZ, leading to the release of GEF from its autoinhibitory state. It further unravels the underlying mutual Dvl2-IPM recognition aspects.
Circular RNA Circ0075305 hinders gastric cancer stem cells by indirectly increasing the expression of RPRD1A. In turn, RPRD1A disrupts TCF4-β-catenin complex formation and promotes downregulation of SOX9 transcription.
This study established a strategy for systemic administration of prodrugs to induce activation in target neurons in the mammalian brain that express Ionotropic Receptors derived from the insect Drosophila melanogaster.
The authors show that the transcription factor E4BP4 mediates the production of anti-inflammatory components that reduce the magnitude of intestinal inflammation in mice.
Pelvimetry and regression analysis show sexual dimorphism in the human fetal pelvis during primary ossification at pelvic inlet, subpubic angle, and the ischial spines’ distance to the transverse diameter of greater pelvis ratio.
Across learning, the brain network transitioned from an integrated state into a segregated state as reflected by an increased modularity value. Replicated across two studies, the speed of the brain state transition was associated with the individual behavioral learning rate.
Human bronchial epithelial cell-derived EVs exhibit immunomodulatory properties through miRNAs & ANXA1, which can suppress NF-κB signaling. The study holds promise as a novel approach for mitigating lung injury and inflammation in acute lung injury.
Golgin45, a Golgi structural protein, is heavily SUMOylated and heat shock stress increases Golgin45 SUMOylation modified by SUMO3 and promotes its inclusion into PML-NBs to transcriptionally regulate lipid metabolism genes.
Efficient phage synthesis yields O157 antigen-specific phages with the detection tag at optimal sites, enabling specific detection of diverse E. coli O157 clinical isolates and suggesting broad applications in bacterial detection and phage therapy.
A survey of known human DNA editing sites with an RNA editing site prediction algorithm suggests APOBEC-mediated RNA editing may produce some of the same protein variants, with the possibility of affecting multiple areas of health.
High levels of placental growth factor can result in a stiffer microenvironment milieu impeding trophoblast invasion of endometrial cells prior to pregnancy, providing insight into the pathogenesis of pre-eclampsia.
Personalized brain activity models in Alzheimer’s disease detect synergistic amyloid-β and tau impacts on neuronal excitability values, which significantly predict brain atrophy, p-tau217 plasma concentrations, and cognitive deterioration.
The authors present DMD-edited microminipigs showing severe Duchenne muscular dystrophy symptoms; their human-like physiology and small size make them ideal for developing new treatments.
A longitudinal study of the circulatory cellular immunity of individuals co-infected with recurrent visceral leishmaniasis and HIV suggests that T cell unresponsiveness underlies visceral leishmaniasis chronicity.
An fMRI study suggests that adaptation to sensorimotor delays when touching one hand with the other dynamically alters the activity in somatosensory and cerebellar regions.
The adaptor protein Disabled 2 (Dab2) regulates the activation and self-renewal of hair follicle stem cells via canonical Wnt pathway. Importantly, Dab2 is also involved in the ageing process.
The epigenetic regulator, N(alpha)-acetyltransferase 40 (NAA40), induced by ecdysone, acetylates histone H4 and modulates ecdysone action in the regulation of insect metamorphosis.