A mechanism study revealing that a sRNA, processed from 3’ UTR of ply operon, responses to O₂ and represses Ply translation post-transcriptionally, ensuring appropriate Ply protein levels in anoxic niches and promoting pneumococcal brain invasion.

Proteomics experiments, metabolomics analyses and network pharmacology combined with molecular biology results suggest that alkaloids of Aconiti Lateralis Radix Praeparata might treat NSCLC by regulating PI3K/Akt-mTOR signaling and glycolysis.

fMRI-neurofeedback targeting a hallucination-related whole-brain network allows individuals to willfully control its temporal properties and modify proneness the hallucination induction, showing promise for investigating future therapies in disease.

Germination of an ancient seed from the Judean desert, confirmed by DNA sequencing and phylogenetic analysis as belonging to an unknown Commiphora sp., contained abundant bioactive compounds, suggesting identification with a resin-producing tree mentioned in Biblical sources.

The immunodominant surface antigen GP60 undergoes dynamic changes in expression profile and localization during parasite invasion and development and is a key molecule mediating host infectivity and pathogenicity.

Analysis of human microglia across health and disease identifies key gene sets in neurodegeneration, offering insights into their role in CNS disorders.

CTBP1 in granulosa cells of PCOS patients represses transcription of aromatase CYP19A1 and regulates stability of SREBP1a, which both contributes to dysregulation of hormone synthesis and lipid metabolism.

GWAS analyses found six consensus significant k-mers associated with host species and the best k-mer predictor achieved a high classification accuracy, offering a simple target for predicting cross-species transmission risk of S. aureus.

Functional connectivity patterns in the brain uniquely identify individuals, even in AD. fMRI data shows that while brain fingerprints remain distinct, they reconfigure to different regions/cognitive functions as the disease progresses.

Magnetite (Fe₃O₄) nanocrystals present in many animal and plant tissues are known to be potent ice nucleating particles. Results from a study on garlic predict the presence of magnetite binding agents in plants that help to prevent frostbite.

In this Q&A, Brianna Bibel, also known as the Bumbling Biochemist, talks to the journal about how social media can be harnessed to relay scientific information to other researchers, while making it fun and accessible.

Conducting research at the interface of chemistry, microbiology and marine biology, Constanze Kuhlisch reports on challenges in science due to COVID and the situation in Israel, while preparing grants to start her own research group.

Embracing the underlying principles and processes of informed proxy consent or relational autonomy consent in human ancient DNA research can transform research.

This comment reports on work done at Harvard Medical School to identify areas for improvement in research rigor, reproducibility, and responsibility in pursuit of continued research excellence.

Documentation of women’s inclusion in Indian academia and conferences by BiasWatchIndia reveals the scale of underrepresentation of women across science, technology, engineering and mathematics.