Supplements

Nature Insight: Glycochemistry & Glycobiology

Vol. 446, No. 7139 pp 999-1051

Glycobiology cover

The importance of carbohydrates in biological processes has long been underappreciated. Armed with new tools for synthesizing, modifying and studying oligosaccharides and glycoconjugates, our understanding of these biomolecules is rapidly improving. This knowledge is also yielding promising candidates for carbohydrate-based diagnostics, drugs and vaccines.

Top

Editorial

Glycochemistry & Glycobiology

Joshua Finkelstein

doi:10.1038/446999a


Top

Reviews

Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines

Danica P. Galonicacute & David Y. Gin

doi:10.1038/nature05813


Unusual sugar biosynthesis and natural product glycodiversification

Christopher J. Thibodeaux, Charles E. Melan´┐Żon & Hung-wen Liu

doi:10.1038/nature05814


Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins

Gerald W. Hart, Michael P. Housley & Chad Slawson

doi:10.1038/nature05815


Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins

Ajit Varki

doi:10.1038/nature05816


Heparan sulphate proteoglycans fine-tune mammalian physiology

Joseph R. Bishop, Manuela Schuksz & Jeffrey D. Esko

doi:10.1038/nature05817


Exploiting the defensive sugars of HIV-1 for drug and vaccine design

Christopher N. Scanlan, John Offer, Nicole Zitzmann & Raymond A. Dwek

doi:10.1038/nature05818


Synthesis and medical applications of oligosaccharides

Peter H. Seeberger & Daniel B. Werz

doi:10.1038/nature05819