The changing landscape of breast cancer prognostic prediction

We increasingly recognize that multiple factors influence disease outcome in breast cancer. A series of papers in the BJC shed new lights on how the method of diagnosis (screen detected versus self-detected), timing of initiation of therapy, factors that influence treatment compliance, and molecular features of the cancer contribute to treatment outcome. Understanding these variables that influence survival is critical for making optimal treatment recommendations in the clinic and also defines areas for future research.

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Nottingham Prognostic Index Plus (NPI+): a modern clinical decision making tool in breast cancer  Open

E A Rakha, D Soria, A R Green, C Lemetre, D G Powe, C C Nolan, J M Garibaldi, G Ball and I O Ellis

British Journal of Cancer 110: 1688-1697; Published online, 11 March 2014; doi:10.1038/bjc.2014.120

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Breast cancer survival and prognosis by screening history  Open

A J Coldman and N Phillips

British Journal of Cancer 110: 556-559; Published online, 03 December 2013; doi:10.1038/bjc.2013.732

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Progesterone receptor expression is an independent prognostic variable in early breast cancer: a population-based study  Open

C A Purdie, P Quinlan, L B Jordan, A Ashfield, S Ogston, J A Dewar and A M Thompson

British Journal of Cancer 110: 565-572; Published online, 03 December 2013; doi:10.1038/bjc.2013.756

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Predicting response and survival in chemotherapy-treated triple-negative breast cancer  Open

A Prat, A Lluch, J Albanell, W T Barry, C Fan, J I Chacón, J S Parker, L Calvo, A Plazaola, A Arcusa, M A Seguí-Palmer, O Burgues, N Ribelles, A Rodriguez-Lescure, A Guerrero, M Ruiz-Borrego, B Munarriz, J A López, B Adamo, M C U Cheang, Y Li, Z Hu, M L Gulley, M J Vidal, B N Pitcher, M C Liu, M L Citron, M J Ellis, E Mardis, T Vickery, C A Hudis, E P Winer, L A Carey, R Caballero, E Carrasco, M Martín, C M Perou and E Alba

British Journal of Cancer 111: 1532-1541; Published online, 07 August 2014; doi:10.1038/bjc.2014.444

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The EndoPredict score provides prognostic information on late distant metastases in ER+/HER2− breast cancer patients  Open

P Dubsky, J C Brase, R Jakesz, M Rudas, C F Singer, R Greil, O Dietze, I Luisser, E Klug, R Sedivy, M Bachner, D Mayr, M Schmidt, M C Gehrmann, C Petry, K E Weber, K Fisch, R Kronenwett, M Gnant and M Filipits

British Journal of Cancer 109: 2959-2964; Published online, 24 October 2013; doi:10.1038/bjc.2013.671

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The predictive impact of body mass index on the efficacy of extended adjuvant endocrine treatment with anastrozole in postmenopausal patients with breast cancer: an analysis of the randomised ABCSG-6a trial  Open

M Gnant, G Pfeiler, H Stöger, B Mlineritsch, F Fitzal, M Balic, W Kwasny, M Seifert, M Stierer, P Dubsky, R Greil, G Steger, H Samonigg, C Fesl and R Jakesz

British Journal of Cancer 109: 589-596; Published online, 18 July 2013; doi:10.1038/bjc.2013.367

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Clinical relevance of lymph node ratio in breast cancer patients with one to three positive lymph nodes  Open

S I Kim, S-H Cho, J S Lee, H-G Moon, W C Noh, H J Youn, B K Ko and B-W Park

British Journal of Cancer 109: 1165-1171; Published online, 13 August 2013; doi:10.1038/bjc.2013.465

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Biology of primary breast cancer in older women treated by surgery: with correlation with long-term clinical outcome and comparison with their younger counterparts  Open

B M Syed, A R Green, E C Paish, D Soria, J Garibaldi, L Morgan, D A L Morgan, I O Ellis and K L Cheung

British Journal of Cancer 108: 1042-1051; Published online, 05 March 2013; doi:10.1038/bjc.2012.601

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Is elective nodal irradiation beneficial in patients with pathologically negative lymph nodes after neoadjuvant chemotherapy and breast-conserving surgery for clinical stage II–III breast cancer? A multicentre retrospective study (KROG 12-05)  Open

J M Noh, W Park, C-O Suh, K C Keum, Y B Kim, K H Shin, K Kim, E K Chie, S W Ha, S S Kim, S D Ahn, H S Shin, J H Kim, H-S Lee, N K Lee, S J Huh and D H Choi

British Journal of Cancer 110: 1420-1426; Published online, 30 January 2014; doi:10.1038/bjc.2014.26

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The value of high adherence to tamoxifen in women with breast cancer: a community-based cohort study  Open

C McCowan, S Wang, A M Thompson, B Makubate and D J Petrie

British Journal of Cancer 109: 1172-1180; Published online, 15 August 2013; doi:10.1038/bjc.2013.464

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Individual risk profiling for breast cancer recurrence: towards tailored follow-up schemes  Open

J Kraeima, S Siesling, I M H Vliegen, J M Klaase and M J IJzerman

British Journal of Cancer 109: 866-871; Published online, 16 July 2013; doi:10.1038/bjc.2013.401

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The association of waiting times from diagnosis to surgery with survival in women with localised breast cancer in England  Open

M T Redaniel, R M Martin, S Cawthorn, J Wade and M Jeffreys

British Journal of Cancer 109: 42-49; Published online, 25 June 2013; doi:10.1038/bjc.2013.317

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Which breast cancer decisions remain non-compliant with guidelines despite the use of computerised decision support?  Open

B Séroussi, C Laouénan, J Gligorov, S Uzan, F Mentré and J Bouaud

British Journal of Cancer 109: 1147-1156; Published online, 13 August 2013; doi:10.1038/bjc.2013.453

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A decision impact, decision conflict and economic assessment of routine Oncotype DX testing of 146 women with node-negative or pNImi, ER-positive breast cancer in the UK  Open

S Holt, G Bertelli, I Humphreys, W Valentine, S Durrani, D Pudney, M Rolles, M Moe, S Khawaja, Y Sharaiha, E Brinkworth, S Whelan, S Jones, H Bennett and C J Phillips

British Journal of Cancer 108: 2250-2258; Published online, 21 May 2013; doi:10.1038/bjc.2013.207