The aim of the Encyclopedia of DNA Elements (ENCODE) project was to map functional elements of the genome. The project initially focused on the human genome but was expanded to include the mouse, which has a premier role as a model organism in biomedical research. In this Online Special, Nature brings together a selection of articles from across publishing houses that collectively describe the key datasets and analyses of the Mouse ENCODE project. The results of the ENCODE project constitute an invaluable resource to the scientific community. Many of the papers collected below also provide a comparison of these functional genome maps, thereby revealing key similarities as well as differences between the mouse and the human.

Credit: Kelly Krause/Nature