Special

Mouse ENCODE

The aim of the Encyclopedia of DNA Elements (ENCODE) project was to map functional elements of the genome. The project initially focused on the human genome but was expanded to include the mouse, which has a premier role as a model organism in biomedical research. In this Online Special, Nature brings together a selection of articles from across publishing houses that collectively describe the key datasets and analyses of the Mouse ENCODE project. The results of the ENCODE project constitute an invaluable resource to the scientific community. Many of the papers collected below also provide a comparison of these functional genome maps, thereby revealing key similarities as well as differences between the mouse and the human.

Credit: Kelly Krause/Nature

Nature
Science
PNAS
Genome research
Blood

Nature

A Comparative Encyclopedia of DNA Elements in the Mouse Genome

The mouse ENCODE consortium et al.

Nature 515, 355–364 ( 19 November 2014 )
Conservation of trans-acting networks during mammalian regulatory evolution

A. B. Stergachis et al.

Nature 515, 365–370 ( 19 November 2014 )
Principles Of Regulatory Information Conservation Between Mouse And Human

Y. Cheng et al.

Nature 515, 371–375 ( 19 November 2014 )
Topologically-associating domains are stable units of replication-timing regulation

B.D. Pope et al.

Nature 515, 402–405 ( 19 November 2014 )
Mice in the ENCODE spotlight

P. Carninci

Nature 515, ( 19 November 2014 )

Science

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution

Vierstra et al.

Science ( 21 November 2014 )

PNAS

Comparison of the transcriptional landscapes between human and mouse tissues

S. Lin et al.

PNAS ( 20 November 2014 )

Genome research

Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis.

M. Pimkin et al

Genome Res ( 15 October 2014 )
Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis.

W. Wu et al

Genome Res ( 15 October 2014 )
Widespread contribution of transposable elements to the innovation of gene regulatory networks.

V. Sundaram et al

Genome Res ( 15 October 2014 )

Blood

Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development.

V. R. Paralkar et al

Blood 123, 1927-1937 ( 20 March 2014 )

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Special

Mouse ENCODE

Nature

A Comparative Encyclopedia of DNA Elements in the Mouse Genome

Conservation of trans-acting networks during mammalian regulatory evolution

Principles Of Regulatory Information Conservation Between Mouse And Human

Topologically-associating domains are stable units of replication-timing regulation

Mice in the ENCODE spotlight

Science

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution

PNAS

Comparison of the transcriptional landscapes between human and mouse tissues

Genome research

Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis.

Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis.

Widespread contribution of transposable elements to the innovation of gene regulatory networks.

Blood

Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development.

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Mouse ENCODE

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