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To mark the launch of our new Cellular and Molecular Biology section in the British Journal of Cancer, we present a series of articles to highlight our best research and reviews in this area. Edited by Colin Goding (Ludwig Institute for Cancer Research, University of Oxford), this dedicated collection provides a curated outlet for studies investigating the molecular events that underpin cancer, including DNA damage, metabolism, apoptosis, resistance mechanisms, dormancy, and heterogeneity. These articles recognise the powerful contribution of cellular and molecular biology to our understanding of cancer progression, and to the development of new and effective anticancer therapies.