Expanding the CRISPR Toolbox

The CRISPR-Cas9 system is best known for its ability to knock out or replace specific genes, via targeted cleavage of the genome. But scientists are developing many more applications, typically by using an inactive Cas9 to target other enzymes to specific genomic sites.  From transcriptional regulation to base editing, these developments are extending the range of biological questions that can be probed with CRISPR/Cas9.

View the animation on CRISPR gene editing and beyond.

View the poster on expanding the CRISPR toolbox.

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The CRISPR-Cas9 system provides efficient ways to knock out or replace genes. This animation explores how CRISPR-Cas9 is being used beyond gene editing. Viewers can follow Cas9 and its different fusion partners as they increase or block gene expression, facilitate specific base changes or illuminate the genome.