Supplements

Building a Cell

Vol. 463, No. 7280 pp 445–492

The buildingacell system cover

In this supplement

A cell is a self-organizing and self-replicating machine. The genome contains the instructions for building this highly complex machine, but how this information is accessed, read and interpreted depends on the cell type and its stage of development. Our understanding of how cellular organization and function are regulated in this way is now rapidly improving.

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Editorial

Building a Cell free access

Deepa Nath, Ritu Dhand & Angela K. Eggleston

doi:10.1038/463445a


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Reviews

Towards building a chromosome segregation machine

Kerry Bloom & Ajit Joglekar

doi:10.1038/nature08912


Expansion of the eukaryotic proteome by alternative splicing

Timothy W. Nilsen & Brenton R. Graveley

doi:10.1038/nature08909


The endocytic matrix

Giorgio Scita & Pier Paolo Di Fiore

doi:10.1038/nature08910


Chromatin remodelling during development

Lena Ho & Gerald R. Crabtree

doi:10.1038/nature08911


Cell mechanics and the cytoskeleton

Daniel A. Fletcher & R. Dyche Mullins

doi:10.1038/nature08908


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