Milestone |

HIV research

Human immunodeficiency virus (HIV) – the etiologic agent of AIDS – is one of the most intensively studied disease organisms in history. Since its first identification in the early 1980s, HIV has transformed into a pandemic, globally infecting more 36 million people and annually contributing to the deaths of hundreds of thousands of patients – particularly in low income countries. This Milestone charts the history of HIV research on an interactive Timeline, from its origins to the latest developments in HIV treatment, vaccines and insights from the study of HIV/AIDS pathogenesis. 

Milestones

Research

Reviews

  • Nature Immunology | Review Article

    HIV devotes a large portion of its coding capacity to counteracting the function of mammalian antiviral proteins. Landau and colleagues discuss the biology of mammalian restriction factors and the viral accessory proteins that counteract them.

    • Viviana Simon
    • , Nicolin Bloch
    •  &  Nathaniel R Landau
  • Nature Reviews Immunology | Review Article

    This article describes recent progress in delineating the factors that contribute to spontaneous HIV-1 immune control, with the ultimate aim of translating these studies into clinical strategies to induce a 'functional cure' of HIV-1 infection.

    • Bruce D. Walker
    •  &  Xu G. Yu
  • Nature Medicine | Perspective

    The International AIDS Society Towards a Cure Working Group lays out its scientific strategy to achieve a cure for HIV.

    • Steven G Deeks
    • , Sharon R Lewin
    • , Anna Laura Ross
    • , Jintanat Ananworanich
    • , Monsef Benkirane
    • , Paula Cannon
    • , Nicolas Chomont
    • , Daniel Douek
    • , Jeffrey D Lifson
    • , Ying-Ru Lo
    • , Daniel Kuritzkes
    • , David Margolis
    • , John Mellors
    • , Deborah Persaud
    • , Joseph D Tucker
    • , Françoise Barre-Sinoussi
    • , International AIDS Society Towards a Cure Working Group
    • , Galit Alter
    • , Judith Auerbach
    • , Brigitte Autran
    • , Dan H Barouch
    • , Georg Behrens
    • , Marina Cavazzana
    • , Zhiwei Chen
    • , Éric A Cohen
    • , Giulio Maria Corbelli
    • , Serge Eholié
    • , Nir Eyal
    • , Sarah Fidler
    • , Laurindo Garcia
    • , Cynthia Grossman
    • , Gail Henderson
    • , Timothy J Henrich
    • , Richard Jefferys
    • , Hans-Peter Kiem
    • , Joseph McCune
    • , Keymanthri Moodley
    • , Peter A Newman
    • , Monique Nijhuis
    • , Moses Supercharger Nsubuga
    • , Melanie Ott
    • , Sarah Palmer
    • , Douglas Richman
    • , Asier Saez-Cirion
    • , Matthew Sharp
    • , Janet Siliciano
    • , Guido Silvestri
    • , Jerome Singh
    • , Bruno Spire
    • , Jeffrey Taylor
    • , Martin Tolstrup
    • , Susana Valente
    • , Jan van Lunzen
    • , Rochelle Walensky
    • , Ira Wilson
    •  &  Jerome Zack
  • Nature Immunology | Review Article

    Sok and Burton highlight recent developments in the discovery and application of antibodies able to neutralize diverse isolates of HIV, known as ‘broadly neutralizing antibodies’.

    • Devin Sok
    •  &  Dennis R. Burton