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On April 25, 1953, the paper describing the famous double-helical structure of DNA was published in Nature. From this discovery blossomed further discoveries in genetics and molecular biology, from identifying genetic bases for diseases to determining how DNA encodes proteins. A mere 50 years later, in April 2003, the Human Genome Project, which sequenced 92% of the human genome, was completed. Today, only 70 years after the discovery of DNA, we have vastly expanded what we can do to – and with – this hereditary molecule, including being able to “search and replace” the genetic code of living organisms and using DNA in forensics. In recognition of DNA Day, this Collection showcases some of these cutting-edge DNA methods.