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Recent advances in single-cell and spatial-omics technology revealed substantial cellular heterogeneity of multicellular organisms. Direct intercellular communication among distinct or similar cell types plays pivotal roles in maintaining tissue homeostasis. As such, cell competition in general supports tissue development and homeostasis; immune cell interactions with infected or transformed cells often takes place in immune responses; symbiotic communication within the stem cell niche brings benefits to both stromal and stem cells to maintain tissue integrity. To help advance this exciting area, Communications Biology welcomes submissions that contribute to our understanding of cell-cell communication in multicellular organisms. We are particularly interested in direct cell-cell communication in development, adult tissue homeostasis, disease pathogenesis, and ageing. In addition to original research Articles, we will also consider Reviews, Perspectives and Comments covering these topics. All submissions will be subject to the same review process as regular Communications Biology Articles.
This Collection supports and amplifies research related to SDG 3.
Various carriers are involved in extracellular Wnt transport. Here, the authors show that Wnt heterodimerization with its carrier protein, sFRP2, enhances Wnt accumulation on the cell surface, leading to exosome-mediated Wnt re-secretion.
A single-cell interaction study on ovarian cancer reveals heterogeneous epithelial-immune-stromal cellular compartments and their interactions in shaping the tumor microenvironment, especially through the NECTIN2-TIGIT interaction.
A single-cell RNA sequencing study about POP constructed a transcriptional profile of 30,452 single cells of the uterosacral ligament in human for the first time, revealing a picture of immune cell infiltration in USL tissue of POP samples.
To facilitate large-scale manufacturing of induced pluripotent stem cells, a Biological System-of-Systems (Bio-SoS) framework is proposed to model cell-to-cell interactions, spatial and metabolic heterogeneity, and cell response to micro-environmental variation.
Wnt/β-catenin signalling activation in the dermis cause fibrosis by cell-autonomous program and by a non-cell-autonomous program mediated by TGF-β niche formation based on Cxcl14-mediated interactions between stromal cells and M2 macrophages.
TimeTalk is a computational approach that uses time-course single-cell RNA-seq data to identify ligand-receptor pairs for studying cell-cell communications in early embryo development.
INPP5E is shown to be involved in the process of proximal TCR signaling activation at the immune synapse by providing a preferable phosphoinositide microenvironment via hydrolyzing PI(4,5)P2 at the plasma membrane, regulating complex formation with CD3ζ, ZAP-70, and Lck, allowing proximal TCR signaling and T cell activation.
A computational method quantifies long-range cell-cell force transmission through the extracellular matrix by correlating ECM remodeling fluctuations in simulations and live 3D imaging and identifies unique signatures of communicating cell pairs.
Analysis of single-cell RNA sequencing data using the CellChat algorithm reveal that changes in the ambient temperature elicit comprehensive alterations of cellcell communications in murine brown adipose tissue
The signaling through α7 nicotinic acetylcholine receptor (α7nAChR) in mouse macrophages has been revealed to enhance macrophage-macrophage interactions in the spleen and has a protective effect on the kidneys.
An indirect CRISPR screening system based on the photoconvertible fluorescent protein, Dendra2, enables the discovery of elements responsible for drug resistance from cell–cell interactions.