Supplements
Proteins to proteomes
Vol. 450, No. 7172 pp 963–1009
In this supplement
Proteins are the most diverse and versatile set of biological macromolecules, having crucial roles in all biological processes. Now that researchers have identified whole complements of proteins (proteomes) for many cell types, they are pushing the frontiers of protein science: from the regulation and function of single protein dynamics to the evolution and inhibition of protein–protein interactions.
Editorial
Proteins to proteomes
Tanguy Chouard & Joshua Finkelstein
doi:10.1038/450963a
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Reviews
Dynamic personalities of proteins
Katherine Henzler-Wildman & Dorothee Kern
doi:10.1038/nature06522
Abstract | Full Text | PDF (663KB)
The molecular sociology of the cell
Carol V. Robinson, Andrej Sali & Wolfgang Baumeister
doi:10.1038/nature06523
Abstract | Full Text | PDF (1,007KB)
The origin of protein interactions and allostery in colocalization
John Kuriyan & David Eisenberg
doi:10.1038/nature06524
Abstract | Full Text | PDF (867KB)
The biological impact of mass-spectrometry-based proteomics
Benjamin F. Cravatt, Gabriel M. Simon & John R. Yates III
doi:10.1038/nature06525
Abstract | Full Text | PDF (4,064KB)
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
James A. Wells & Christopher L. McClendon
doi:10.1038/nature06526
Abstract | Full Text | PDF (533KB) | Supplementary information