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Neurodegeneration
Vol. 443, No. 7113 pp767-803
The prevalence of neurodegenerative disorders such as Alzheimer�s disease and Parkinson�s disease is increasing, but effective treatments are lacking. Researchers have revealed many parallels among this diverse group of disorders, including protein aggregation and mitochondrial dysfunction. It is hoped that greater understanding of these processes and their role in disease will lead to new treatments.
Editorial
Neurodegeneration
Marie-Th�r�se Heemels
doi:10.1038/443767a
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Reviews
A network dysfunction perspective on neurodegenerative diseases Free access
Jorge J. Palop, Jeannie Chin and Lennart Mucke
doi:10.1038/nature05289
Abstract |Full Text | PDF (468KB)
A century-old debate on protein aggregation and neurodegeneration enters the clinic
Peter T. Lansbury and Hilal A. Lashuel
doi:10.1038/nature05290
Abstract | Full Text | PDF (367KB)
The roles of intracellular protein-degradation pathways in neurodegeneration
David C. Rubinsztein
doi:10.1038/nature05291
Abstract | Full Text | PDF (485KB)
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin and M. Flint Beal
doi:10.1038/nature05292
Abstract | Full Text | PDF (581KB)
Cell death in the nervous system
Dale E. Bredesen, Rammohan V. Rao and Patrick Mehlen
doi:10.1038/nature05293
Abstract | Full Text | PDF(519KB)
Prions and their partners in crime
Byron Caughey and Gerald S. Baron
doi:10.1038/nature05294
Abstract | Full Text | PDF (3,287KB)