Open Questions in Chemistry

In spite of decades of research and the enormous progress made, chemists continue to grapple with poorly understood aspects of the world around us. Indeed, many fundamental questions remain— will we ever get to the bottom of the different structures of ice, or pinpoint the origins of life on Earth, or obtain a full picture of the complexity of carbon-based molecules in space?

This collection aims to uncover open questions across the breadth of the chemical sciences. Each Comment provides an overview of a focused field of research, identifies key open questions, and gives expert opinion on how challenges in answering these questions might be overcome. Our hope is that this series will be of interest to the chemistry community as a whole, and that it will stimulate those working in or adjacent to the research fields that are covered to think about some of the open questions that invite further study.



Organic chemistry and chemical biology

Inorganic chemistry

Physical chemistry