3D genome organisation

Development of new techniques for chromosome configuration capture, utilising in particular - but not only - the benefits of next generation sequencing, has allowed us to probe the three dimensional structure of the genome and to study its complex role in gene regulation in new and exciting ways. This Collection will focus on further methodological advances in this field as well as on the applications of these new techniques to study nuclear organization and how genome architecture regulates gene expression.

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Joanna M. Bridger is a Professor at Brunel University London and is the Director of the Centre for Genome Engineering and Maintenance (CenGEM). Prof Bridger’s group investigates active and functional chromosome and gene loci dynamics in interphase nuclei, aberrant nuclear structure and its impact on genome organisation and function. Her lab has research interests in genome behaviour in premature and normal ageing, female cancers and interfering with pathogen-mediated host genome manipulation. Prof Bridger has been an Editorial Board Member for Scientific Reports since 2015. 


Elissa P. Lei is a Senior Investigator and Chief of the Nuclear Organization and Gene Expression Section in the Laboratory of Biochemistry and Genetics at the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health. She obtained her Ph.D. from Harvard Medical School in the laboratory of Dr. Pamela A. Silver and trained at Johns Hopkins University in the laboratory of Dr. Victor G. Corces as a Jane Coffin Childs Memorial Fund for Medical Research Postdoctoral Fellow. Dr Lei has been an Editorial Board Member for Scientific Reports since 2019.


Asli Silahtaroglu is an Associate Professor in Medical Genetics at the Department of Cellular and Molecular Medicine, University of Copenhagen, Faculty of Health and Medical Sciences. She is interested in genome-wide and locus specific mechanisms regulating and fine-tuning gene expression like 3D genome organization, non-coding RNAs and epigenetics. She also likes methodological projects pushing the limitations to visualize these events taking place within the nucleus through interdisciplinary collaborations. Dr Silahtaroglu has been an Editorial Board Member for Scientific Reports since 2018.