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Transcription and epigenetics

Vol. 502 No. 7472 pp461-506

In this Supplement
- Editorial
- Articles
Transcriptional programs dictate cell identity during development. This Insight highlights recent advances in transcriptional and epigenetic regulation during development and disease, including the mechanisms behind reprogramming and DNA demethylation, the role of chromosome topology, links to metabolism and small molecule drug discovery.

Credit: Illustration by Nik Spencer. Concept by Effie Apostolou and John Bardakos

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Transcription and epigenetics
- Alex Eccleston
- Francesca Cesari
- Magdalena Skipper
Nature 502, 461 (24 October 2013)

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Chromatin dynamics during cellular reprogramming
- Effie Apostolou
- Konrad Hochedlinger
Nature 502, 462-471 (24 October 2013)
TET enzymes, TDG and the dynamics of DNA demethylation
- Rahul M. Kohli
- Yi Zhang
Nature 502, 472-479 (24 October 2013)
Chromatin proteins and modifications as drug targets
- Kristian Helin
- Dashyant Dhanak
Nature 502, 480-488 (24 October 2013)
The nexus of chromatin regulation and intermediary metabolism
- Philipp Gut
- Eric Verdin
Nature 502, 489-498 (24 October 2013)
Topology of mammalian developmental enhancers and their regulatory landscapes
- Wouter de Laat
- Denis Duboule
Nature 502, 499-506 (24 October 2013)