Sexual medicine: Experts debate—should DSM-V raise the bar for female sexual dysfunction diagnosis?

Annette Fenner

doi:10.1038/nrurol.2012.171

Nature Reviews Urology 9, 475 (2012)

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Sexual medicine: Increased PDE5 levels in a mouse model of type 2 diabetes

Annette Fenner

doi:10.1038/nrurol.2012.153

Nature Reviews Urology 9, 476 (2012)

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Sexual medicine: Pain and pleasure—reconstruction after female genital mutilation

Mina Razzak

doi:10.1038/nrurol.2012.152

Nature Reviews Urology 9, 477 (2012)

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Sexual medicine: PDE5 inhibitor protects testes

Sarah Payton

doi:10.1038/nrurol.2012.170

Nature Reviews Urology 9, 477 (2012)

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Sexual medicine: Combined contraceptives—which delivery route is best?

Mina Razzak

doi:10.1038/nrurol.2012.155

Nature Reviews Urology 9, 478 (2012)

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Sexual medicine: Rapid-onset avanafil effective for ED

Annette Fenner

doi:10.1038/nrurol.2012.154

Nature Reviews Urology 9, 477 (2012)

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Sexual medicine: Can pelvic measurements predict gender identity disorder?

Melanie Clyne

doi:10.1038/nrurol.2012.159

Nature Reviews Urology 9, 478 (2012)

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Sexual medicine: Long-acting testosterone injection is well-tolerated and effective

doi:10.1038/nrurol.2012.160

Nature Reviews Urology 9, 476 (2012)

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Sexual medicine: Fewer infections after antibiotic-impregnated penile prosthesis replacement surgery

doi:10.1038/nrurol.2012.161

Nature Reviews Urology 9, 476 (2012)

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Sexual medicine: 'Snodgraft' modification for hypospadias repair

doi:10.1038/nrurol.2012.162

Nature Reviews Urology 9, 476 (2012)

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Sexual medicine: Supersensitive fluorescent semen analysis identifies sperm in more samples than conventional analysis

doi:10.1038/nrurol.2012.163

Nature Reviews Urology 9, 476 (2012)

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Sexual medicine: When good isn't good enough—treatment for vulvodynia

Ruby H. N. Nguyen

doi:10.1038/nrurol.2012.145

Nature Reviews Urology 9, 482-483 (2012)

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Sexual medicine: Online risks to health—the problem of counterfeit drugs

Bryan A. Liang & Tim K. Mackey

doi:10.1038/nrurol.2012.148

Nature Reviews Urology 9, 480-482 (2012)

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Sexual medicine: The psychological effects of recreational PDE5 inhibitor use

Tamara Melnik

doi:10.1038/nrurol.2012.149

Nature Reviews Urology 9, 479-480 (2012)

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Sexual medicine: Why stop a good thing? Discontinuing PDE5 inhibitors

Helen M. Conaglen & John V. Conaglen

doi:10.1038/nrurol.2012.165

Nature Reviews Urology 9, 483-485 (2012)

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Sex for fun: a synthesis of human and animal neurobiology

Janniko R. Georgiadis, Morten L. Kringelbach & James G. Pfaus

doi:10.1038/nrurol.2012.151

Nature Reviews Urology 9, 486-498 (2012)

Georgiadis et al. provide a comprehensive description of the available animal and human literature on sexual reward and sexual incentive motivation, highlighting the major points of convergence and divergence across species. They discuss a neural concept of human sexual behavioural control and suggest novel testable hypotheses for future sex research.

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The hormonal control of ejaculation

Giovanni Corona, Emmanuele A. Jannini, Linda Vignozzi, Giulia Rastrelli & Mario Maggi

doi:10.1038/nrurol.2012.147

Nature Reviews Urology 9, 508-519 (2012)

Owing to the expansive nervous components participating in the ejaculation reflex, that multiple neurotransmitters are involved is unsurprising. In this Review, the authors focus on the endocrine control of the ejaculatory reflex and suggest that widely available endocrine therapies might be effective in treating sexual disorders such as premature ejaculation.

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Therapeutic strategies for patients with micropenis or penile dysmorphic disorder

Oliver Kayes, Majid Shabbir, David Ralph & Suks Minhas

doi:10.1038/nrurol.2012.150

Nature Reviews Urology 9, 499-507 (2012)

In this Review, Kayes and colleagues discuss the aetiology, diagnosis and treatment options for congenital micropenis, acquired micropenis and penile dysmorphic disorder, including both nonsurgical and surgical techniques. They evaluate the role of phalloplasty and penile replacement surgery including transplantation, in this challenging clinical area.

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Emerging tools for erectile dysfunction: a role for regenerative medicine

Lukman Hakim, Frank Van der Aa, Trinity J. Bivalacqua, Petter Hedlund & Maarten Albersen

doi:10.1038/nrurol.2012.143

Nature Reviews Urology 9, 520-536 (2012)

Men with erectile dysfunction (ED) that is unresponsive to available oral pharmacotherapy with PDE5 inhibitors represent a significant subgroup of patients with the disorder. Such patients might in the near future benefit from regenerative medicine options that restore tissue integrity and signalling in penis-projecting neurons, penile smooth muscle cells and endothelial cells. In this comprehensive Review, the authors discuss the current cutting-edge research in regenerative medicine for ED and consider the therapeutic potential of these techniques for the future.

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Challenges in sexual medicine

Selim Cellek & Annamaria Giraldi

doi:10.1038/nrurol.2012.134

Nature Reviews Urology 9, 537-542 (2012)

Sexual medicine represents one of the newest medical specialties—indeed it has only recently been recognized as a specialty in its own right. Although research in sexual medicine is at the cutting edge of some of the newest techniques, obstacles remain. Here, Cellek and Giraldi discuss the challenges faced by sexual medicine as a field, including funding difficulties, taboos and female sexual dysfunction.

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