Supplements
RNA silencing
Vol. 457, No. 7228 pp 395–433
In this supplement
In the past decade, the idea that RNA is just a passive carrier of information has been overturned. Small non-coding RNA molecules are now known to be important regulators of gene expression and genome integrity. With recent technological advances, the molecular mechanisms of these RNA silencing pathways are becoming clearly defined, and their components are now being tested in clinical trials.
Editorial
RNA silencing free access
Angela K. Eggleston
doi:10.1038/457395a
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Reviews
On the road to reading the RNA-interference code
Haruhiko Siomi & Mikiko C. Siomi
doi:10.1038/nature07754
Abstract | Full Text | PDF (1,632KB)
A three-dimensional view of the molecular machinery of RNA interference
Martin Jinek & Jennifer A. Doudna
doi:10.1038/nature07755
Abstract | Full Text | PDF (2,500KB)
Small RNAs in transcriptional gene silencing and genome defence
Danesh Moazed
doi:10.1038/nature07756
Abstract | Full Text | PDF (1,787KB)
Viral and cellular messenger RNA targets of viral microRNAs
Bryan R. Cullen
doi:10.1038/nature07757
Abstract | Full Text | PDF (1,768KB)
The promises and pitfalls of RNA-interference-based therapeutics
Daniela Castanotto & John J. Rossi
doi:10.1038/nature07758
Abstract | Full Text | PDF (2,642KB)
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