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Gene targeting Nobel prize

In this supplement

The 2007 Nobel Prize in Medicine went to Mario Capecchi, Oliver Smithies and Martin Evans, who pioneered a technology for disrupting or altering mouse genes at will. Around half of all mouse genes have now been disrupted using this gene-knockout technology. This special Nature collection explores how, in combination with advances in genomics, the technique has led to a revolution in biomedical science by linking genes to processes of disease and development that are, more often than not, similar in both mice and humans.

Nobel medal image: Science Museum/Science & Society Picture Library

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The Collection

EDITORIAL

Gene targeting Nobel prize celebration

Natalie DeWitt

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NEWS

Biologists claim Nobel prize with a knock-out

Alison Abbott

NatureNews 9 October 2007 doi:10.1038/449642a

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PERSPECTIVE

Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century

Mario R. Capecchi

Nat. Rev. Genet. 6, 507–512 (June 2005) doi:10.1038/nrg1619

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COMMENTARY

Generating mice with targeted mutations

Mario R. Capecchi

Nat. Med. 7, 1086–1090 (October 2001) doi:10.1038/nm1001-1086

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COMMENTARY

Forty years with homologous recombination

Oliver Smithies

Nat. Med. 7, 1083–1086 (October 2001) doi:10.1038/nm1001-1083

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COMMENTARY

The cultural mouse

Martin J. Evans

Nat. Med. 7, 1081–1083 (October 2001) doi:10.1038/nm1001-1081

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ARTICLE

Production of a model for Lesch–Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice

Chao-Liang Wu & David W. Melton

Nat. Genet. 3, 235–240 (01 March 1993) doi:10.1038/ng0393-235

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ARTICLE

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Lawrence A. Donehower et al.

Nature 356, 215–221 (19 March 1992) doi:10.1038/356215a0

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LETTER

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

Kirk R. Thomas & Mario R. Capecchi

Nature 346, 847–850 (30 August 1990) doi:10.1038/346847a0

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LETTER

Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells

Maarten Zijlstra, En Li, Fereydoun Sajjadi, Suresh Subramani & Rudolf Jaenisch

Nature 342, 435–438 (23 November 1989) doi:10.1038/342435a0

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LETTER

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas & Mario R. Capecchi

Nature 336, 348–352 (24 November 1988) doi:10.1038/336348a0

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LETTER

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

Thomas Doetschman et al.

Nature 330, 576–578 (10 December 1987) doi:10.1038/330576a0

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LETTER

A potential animal model for Lesch–Nyhan syndrome through introduction of HPRT mutations into mice

Michael R. Kuehn, Allan Bradley, Elizabeth J. Robertson & Martin J. Evans

Nature 326, 295–298 (25 March 1987) doi:10.1038/326295a0

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LETTER

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

Martin Hooper, Kate Hardy, Alan Handyside, Susan Hunter & Marilyn Monk

Nature 326, 292–295 (25 March 1987) doi:10.1038/326292a0

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ARTICLE

Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene

Kirk R. Thomas & Mario R. Capecchi

Nature 324, 34–38 (06 November 1986) doi:10.1038/324034a0

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LETTER

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

Elizabeth Robertson, Allan Bradley, Michael Kuehn & Martin Evans

Nature 323, 445–448 (02 October 1986) doi:10.1038/323445a0

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ARTICLE

Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination

Oliver Smithies, Ronald G. Gregg, Sallie S. Boggs, Michael A. Koralewski & Raju S. Kucherlapati

Nature 317, 230–234 (19 September 1985) doi:10.1038/317230a0

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LETTER

Establishment in culture of pluripotential cells from mouse embryos

M. J. Evans & M. H. Kaufman

Nature 292, 154–156 (09 July 1981) doi:10.1038/292154a0

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LETTER

Fate of teratocarcinoma cells injected into early mouse embryos

V. E. Papaioannou, M. W. Mcburney, R. L. Gardner & M. J. Evans

Nature 258, 70–73 (06 November 1975) doi:10.1038/258070a0

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ARTICLE

Chromosomal rearrangements and the evolution of haptoglobin genes

O. Smithies, G. E. Connell & G. H. Dixon

Nature 196, 232–236 (20 October 1962) doi:10.1038/196232a0

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