Outlook: Chagas Disease

Vol. 465, No. 7301 suppl. ppS3-S22

Chagas Disease

In this supplement

Chagas disease is one of the most neglected of the tropical diseases, yet millions of people are infected with it. There are only two available drugs to treat it, both of which are more than 40 years old and neither of which is ideal. As the global population has become more internationally mobile, Chagas disease has spread from Latin America to become a worldwide threat. This Outlook highlights some of the progress in understanding and treating Chagas disease over its 101 years of recent history and outlines the challenges still to be met.




Chagas disease

Michelle Grayson

Nature 465, S3 (24 June 2010) doi:10.1038/465S3a


Chagas disease 101

Julie Clayton

Nature 465, S4—S5 (24 June 2010) doi:10.1038/nature09220


Chagas disease: a new worldwide challenge

José Rodrigues Coura & Pedro Albajar Viñas

Nature 465, S6—S7 (24 June 2010) doi:10.1038/nature09221


Who, how, what and where?

Nature 465, S8—S9 (24 June 2010) doi:10.1038/nature09222


Country by country

Anna Petherick

Nature 465, S10—S11 (24 June 2010) doi:10.1038/nature09223


Chagas disease: pushing through the pipeline

Julie Clayton

Nature 465, S12—S15 (24 June 2010) doi:10.1038/nature09224


The promise of T. cruzi genomics

Julie Clayton

Nature 465, S16—S17 (24 June 2010) doi:10.1038/nature09225


Chagas disease in the Chaco

Anna Petherick

Nature 465, S18—S20 (24 June 2010) doi:10.1038/nature09226


Campaigning for Chagas disease

Anna Petherick

Nature 465, S21—S22 (24 June 2010) doi:10.1038/nature09227



News and Views

Parasitology: Triple genome triumph — Free access

Declan Butler

Nature 436, 337—337 (21 July 2005) doi:10.1038/436337b


Immunology south of the equator in the Americas — Free access

Gabriel A. Rabinovich, Alexis M. Kalergis, Norberto W. Zwirner & Wilson Savino

Nature Immunology 9, 1087—1090 (2008) doi:10.1038/ni1008-1087


Trypanosoma cruzi surface mucins: host-dependent coat diversity — Free access

Carlos A. Buscaglia, Vanina A. Campo, Alberto C. C. Frasch & Javier M. Di Noia

Nature Reviews Microbiology 4, 229—236 (March 2006) doi:10.1038/nrmicro1351


Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease — Free access

Juan M. Bustamante, Lisa M. Bixby & Rick L. Tarleton

Nature Medicine 14, 542—550 (20 April 2008) doi:10.1038/nm1744


The Trypanosoma cruzi-host-cell interplay: location, invasion, retention — Free access

Luciana O. Andrade & Norma W. Andrews

Nature Reviews Microbiology 3, 819—823 (9 September 2005) doi:10.1038/nrmicro1249