Immunoengineering

Content

• 

  Jumping to our defence

  The first clinical success of immunotherapeutics for cancer treatment and the appreciation that tissue regeneration can be greatly improved by precisely and locally modulating the immune response are evidence that immunotherapy is poised to revolutionize the way we treat disease.

  Editorial31 May 2019 Nature Reviews Materials
• 

  Multiscale engineering of immune cells and lymphoid organs

  Engineering immune cells and organs using materials enables the investigation of immune responses and the development of immunotherapies. In this Review, the authors discuss 2D and 3D approaches to recreate key cell-level, tissue-level and organ-level immune functionalities of primary, secondary and tertiary lymphoid organs.

  • Sungwoong Kim
  • Shivem B. Shah
  • Ankur Singh

  Review Article3 Apr 2019 Nature Reviews Materials
• 

  Macroscale biomaterials strategies for local immunomodulation

  Macroscale delivery devices can be used to manipulate innate and adaptive immune responses. In this Review, the authors highlight important cellular targets of immunotherapies in tissue repair and cancer and discuss macroscale biomaterials strategies for therapeutic immunomodulation.

  • Maxence O. Dellacherie
  • Bo Ri Seo
  • David J. Mooney

  Review Article23 Apr 2019 Nature Reviews Materials
• 

  Cancer nanomedicine for combination cancer immunotherapy

  Cancer nanomedicine in combination with immunotherapies offers the possibility to amplify antitumour immune responses and to sensitize tumours to immunotherapies. In this Review, the authors discuss combination immunotherapy based on nanoparticle platforms designed for chemotherapy, photothermal therapy, photodynamic therapy, radiotherapy and gene therapy.

  • Jutaek Nam
  • Sejin Son
  • James J. Moon

  Review Article26 Apr 2019 Nature Reviews Materials
• 

  Material design for lymph node drug delivery

  Nanoscale and microscale materials can be used as drug delivery vehicles to target specific lymph node-resident cell subtypes for immunotherapy. In this Review, the authors discuss the transport mechanisms to and from lymph nodes and how they can be explored for drug delivery.

  • Alex Schudel
  • David M. Francis
  • Susan N. Thomas

  Review Article2 May 2019 Nature Reviews Materials
• 

  Engineering immunomodulatory biomaterials for type 1 diabetes

  Type 1 diabetes is an autoimmune disease that causes the destruction of pancreatic β-cells, which results in an insulin deficiency. In this Review, the authors discuss immunomodulatory biomaterials for β-cell replacement and for the induction of tolerogenic immune responses to prevent, delay or reverse the disease.

  • C. L. Stabler
  • Y. Li
  • B. G. Keselowsky

  Review Article17 May 2019 Nature Reviews Materials
• 

  Precision immunomodulation with synthetic nucleic acid technologies

  Nucleic acid scaffolds can be precisely interfaced with cellular components, making them interesting materials to probe and program immune cells. In this Perspective, the authors explore nucleic acid technologies for the quantitative detection of single immune cells and for modulating the immune response.

  • Maulik S. Jani
  • Aneesh T. Veetil
  • Yamuna Krishnan

  Perspective4 Apr 2019 Nature Reviews Materials

• Designing biofunctional immunotherapies

  Intelligent design of materials for biomedical applications involves the development of technologies that are informed by an understanding of biological systems. Immunoengineers have been making essential inroads in developing therapeutics endowed with designed biofunctionality, particularly in vaccinology, cancer immunotherapy and immune tolerance.

  • Elyse A. Watkins
  • Jeffrey A. Hubbell

  Comment8 Mar 2019 Nature Reviews Materials
• 

  Plant viruses join forces

  • Christine-Maria Horejs

  Research Highlight10 May 2019 Nature Reviews Materials
• 

  Cutting ties

  • Christine-Maria Horejs

  Research Highlight15 May 2019 Nature Reviews Materials