[Special Feature] The Epitranscriptome in Development and Disease

The transcriptomic plasticity conferred by post-transcriptional regulation is a fundamental mechanism driving the diversity of proteomes in biological systems. Similar to epigenetic modifications on DNA and histone proteins, RNA is also subject to various chemical modifications, called epitranscriptomic modifications. Notably, recent studies suggested that epitranscriptomic modifications influence almost all aspects of RNA metabolism, including stability, splicing, localization, and translation, enabling precise and flexible control of gene expression. The special issue provides comprehensive reviews of technological advances to investigate the epitranscriptome and the functional contribution of epitranscriptomic regulations in different physiological contexts and the status of human diseases.