Collection 18 February 2020

The best of Gene Therapy 2018 - 2019

See what scientists world-wide have been citing, reading and sharing. In this Web Collection we highlight a selection of articles from 2018 and 2019 which top the list of the journal's most cited, most read and most shared (including press coverage and Twitter). They showcase the breadth of scope and coverage that Gene Therapy consistently delivers to its readers.

Content

Driving cars to the clinic for solid tumors
- Mauro Castellarin
- Keisuke Watanabe
- Avery D. Posey Jr.
CommentOpen Access7 Jun 2018 Gene Therapy
CCAT1 stimulation of the symmetric division of NSCLC stem cells through activation of the Wnt signalling cascade
- C Xu
- G Xiao
- X Sun
Original Article19 Jan 2018 Gene Therapy
AAV-mediated NT-3 overexpression protects cochleae against noise-induced synaptopathy
- Hengchao Chen
- Yazhi Xing
- Jian Wang
ArticleOpen Access13 Mar 2018 Gene Therapy
Downreguation of FoxM1 by miR-214 inhibits proliferation and migration in hepatocellular carcinoma
- Chuan Tian
- Haixia Wu
- Wei Song
Brief Communication4 Jul 2018 Gene Therapy
Widespread transduction of astrocytes and neurons in the mouse central nervous system after systemic delivery of a self-complementary AAV-PHP.B vector
- Melvin Y. Rincon
- Filip de Vin
- Matthew G. Holt
Article9 Mar 2018 Gene Therapy
Understanding the molecular biology of intervertebral disc degeneration and potential gene therapy strategies for regeneration: a review
- Prasanthi Sampara
- Rajkiran Reddy Banala
- Subbaiah GPV
Comment22 Mar 2018 Gene Therapy
LncRNA FTX sponges miR-215 and inhibits phosphorylation of vimentin for promoting colorectal cancer progression
- Yi Yang
- Jinpei Zhang
- Tao Wu
Article20 Jun 2018 Gene Therapy
Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor
- A J Valkama
- H M Leinonen
- H P Lesch
Original ArticleOpen Access5 Oct 2017 Gene Therapy
HIV infection alters the human epigenetic landscape
- Lei Chen
- Shiqi Zhang
- Yu-Dong Cai
Article15 Nov 2018 Gene Therapy
Long noncoding RNA Meg3 regulates cardiomyocyte apoptosis in myocardial infarction
- Hongchun Wu
- Zhen-Ao Zhao
- Shijun Hu
Article4 Oct 2018 Gene Therapy
Fludarabine and neurotoxicity in engineered T-cell therapy
- Kate L. Lowe
- Crystal L. Mackall
- Gwendolyn Binder
CommentOpen Access7 May 2018 Gene Therapy
Rationally designed AAV2 and AAVrh8R capsids provide improved transduction in the retina and brain
- Jennifer A. Sullivan
- Lisa M. Stanek
- Abraham Scaria
Brief Communication22 May 2018 Gene Therapy
Improving therapeutic efficacy of IL-12 intratumoral gene electrotransfer through novel plasmid design and modified parameters
- C. Burkart
- A. Mukhopadhyay
- D. A. Canton
Brief Communication9 Mar 2018 Gene Therapy
AAV1.NT-3 gene therapy increases muscle fiber diameter through activation of mTOR pathway and metabolic remodeling in a CMT mouse model
- Mehmet E. Yalvac
- Jakkrit Amornvit
- Zarife Sahenk
Brief Communication9 Mar 2018 Gene Therapy
Inhibition of microRNA-495 suppresses chondrocyte apoptosis through activation of the NF-κB signaling pathway by regulating CCL4 in osteoarthritis
- Da-Wei Yang
- Gui-Bin Qian
- Kun-Zheng Wang
Article2 Apr 2019 Gene Therapy
Serotype survey of AAV gene delivery via subconjunctival injection in mice
- Liujiang Song
- Telmo Llanga
- Matthew L. Hirsch
Article2 Aug 2018 Gene Therapy
Efficacy of combining ING4 and TRAIL genes in cancer-targeting gene virotherapy strategy: first evidence in preclinical hepatocellular carcinoma
- A Galal El-Shemi
- A Mohammed Ashshi
- C-O Yun
Original ArticleOpen Access19 Sep 2017 Gene Therapy
Scaffold-mediated delivery for non-viral mRNA vaccines
- Ruying Chen
- Hong Zhang
- James D. Bryers
Article21 Sep 2018 Gene Therapy
Targeted in vivo knock-in of human alpha-1-antitrypsin cDNA using adenoviral delivery of CRISPR/Cas9
- Calvin J. Stephens
- Elena Kashentseva
- David T. Curiel
Brief CommunicationOpen Access27 Mar 2018 Gene Therapy
AAV-9 mediated phosphatase-1 inhibitor-1 overexpression improves cardiac contractility in unchallenged mice but is deleterious in pressure-overload
- D M Schwab
- L Tilemann
- O J Müller
Original Article19 Jan 2018 Gene Therapy
Measles vector as a multigene delivery platform facilitating iPSC reprogramming
- Qi Wang
- Alanna Vossen
- Patricia Devaux
Article4 Feb 2019 Gene Therapy
Combination of cabazitaxel and p53 gene therapy abolishes prostate carcinoma tumor growth
- Rodrigo Esaki Tamura
- Marlous G. Lana
- Bryan E. Strauss
Article29 Mar 2019 Gene Therapy
Delivering cellular and gene therapies to patients: solutions for realizing the potential of the next generation of medicine
- Kris Elverum
- Maria Whitman
Review ArticleOpen Access25 Apr 2019 Gene Therapy
Production of lentiviral vectors using novel, enzymatically produced, linear DNA
- Rajvinder Karda
- John R. Counsell
- Simon N. Waddington
ArticleOpen Access14 Jan 2019 Gene Therapy
Excessive activated T-cell proliferation after anti-CD19 CAR T-cell therapy
- Wen-ying Zhang
- Yang Liu
- Wei-dong Han
Article29 Mar 2018 Gene Therapy
Bicistronic transfer of CDKN2A and p53 culminates in collaborative killing of human lung cancer cells in vitro and in vivo
- Juliana G. Xande
- Ana P. Dias
- Eugenia Costanzi-Strauss
Article22 Aug 2019 Gene Therapy
Cell therapy for Parkinson′s disease is coming of age: current challenges and future prospects with a focus on immunomodulation
- Shirley D. Wenker
- Fernando J. Pitossi
Review Article16 Apr 2019 Gene Therapy
Distinct transduction of muscle tissue in mice after systemic delivery of AAVpo1 vectors
- Warut Tulalamba
- Jonas Weinmann
- Dirk Grimm
Brief Communication17 Oct 2019 Gene Therapy
Astrocyte-selective AAV gene therapy through the endogenous GFAP promoter results in robust transduction in the rat spinal cord following injury
- Jarred M. Griffin
- Barbara Fackelmeier
- Simon J. O’Carroll
ArticleOpen Access8 Apr 2019 Gene Therapy
AAV9 Vector: a Novel modality in gene therapy for spinal muscular atrophy
- Rithu Pattali
- Yongchao Mou
- Xue-Jun Li
Review Article26 Jun 2019 Gene Therapy
Gene therapy of hematological disorders: current challenges
- Amr M. Al-Saif
Review Article12 Jul 2019 Gene Therapy
Beyond cystic fibrosis transmembrane conductance regulator therapy: a perspective on gene therapy and small molecule treatment for cystic fibrosis
- Elena K. Schneider-Futschik
Review Article12 Jul 2019 Gene Therapy
Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA
- Anna K. Blakney
- Paul F. McKay
- Robin J. Shattock
ArticleOpen Access12 Jul 2019 Gene Therapy
Genetic therapies, human genetic enhancement, and … eugenics?
- Theodore Friedmann
Editorial4 Jul 2019 Gene Therapy
Safety and efficacy evaluations of an adeno-associated virus variant for preparing IL10-secreting human neural stem cell-based therapeutics
- Mira Cho
- Kwangsoo Jung
- Jae-Hyung Jang
Article28 Jan 2019 Gene Therapy

The best of Gene Therapy 2018 - 2019

Content

Driving cars to the clinic for solid tumors

CCAT1 stimulation of the symmetric division of NSCLC stem cells through activation of the Wnt signalling cascade

AAV-mediated NT-3 overexpression protects cochleae against noise-induced synaptopathy

Downreguation of FoxM1 by miR-214 inhibits proliferation and migration in hepatocellular carcinoma

Widespread transduction of astrocytes and neurons in the mouse central nervous system after systemic delivery of a self-complementary AAV-PHP.B vector

Understanding the molecular biology of intervertebral disc degeneration and potential gene therapy strategies for regeneration: a review

LncRNA FTX sponges miR-215 and inhibits phosphorylation of vimentin for promoting colorectal cancer progression

Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor

HIV infection alters the human epigenetic landscape

Long noncoding RNA Meg3 regulates cardiomyocyte apoptosis in myocardial infarction

Fludarabine and neurotoxicity in engineered T-cell therapy

Rationally designed AAV2 and AAVrh8R capsids provide improved transduction in the retina and brain

Improving therapeutic efficacy of IL-12 intratumoral gene electrotransfer through novel plasmid design and modified parameters

AAV1.NT-3 gene therapy increases muscle fiber diameter through activation of mTOR pathway and metabolic remodeling in a CMT mouse model

Inhibition of microRNA-495 suppresses chondrocyte apoptosis through activation of the NF-κB signaling pathway by regulating CCL4 in osteoarthritis

Serotype survey of AAV gene delivery via subconjunctival injection in mice

Efficacy of combining ING4 and TRAIL genes in cancer-targeting gene virotherapy strategy: first evidence in preclinical hepatocellular carcinoma

Scaffold-mediated delivery for non-viral mRNA vaccines

Targeted in vivo knock-in of human alpha-1-antitrypsin cDNA using adenoviral delivery of CRISPR/Cas9

AAV-9 mediated phosphatase-1 inhibitor-1 overexpression improves cardiac contractility in unchallenged mice but is deleterious in pressure-overload

Measles vector as a multigene delivery platform facilitating iPSC reprogramming

Combination of cabazitaxel and p53 gene therapy abolishes prostate carcinoma tumor growth

Delivering cellular and gene therapies to patients: solutions for realizing the potential of the next generation of medicine

Production of lentiviral vectors using novel, enzymatically produced, linear DNA

Excessive activated T-cell proliferation after anti-CD19 CAR T-cell therapy

Bicistronic transfer of CDKN2A and p53 culminates in collaborative killing of human lung cancer cells in vitro and in vivo

Cell therapy for Parkinson′s disease is coming of age: current challenges and future prospects with a focus on immunomodulation

Distinct transduction of muscle tissue in mice after systemic delivery of AAVpo1 vectors

Astrocyte-selective AAV gene therapy through the endogenous GFAP promoter results in robust transduction in the rat spinal cord following injury

AAV9 Vector: a Novel modality in gene therapy for spinal muscular atrophy

Gene therapy of hematological disorders: current challenges

Beyond cystic fibrosis transmembrane conductance regulator therapy: a perspective on gene therapy and small molecule treatment for cystic fibrosis

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

Genetic therapies, human genetic enhancement, and … eugenics?

Safety and efficacy evaluations of an adeno-associated virus variant for preparing IL10-secreting human neural stem cell-based therapeutics

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