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Persistent thrombocytopenia post auto-SCT for AML treated with romiplostim in a patient with HIV

Bone Marrow Transplantation volume 46, pages 1280–1281 (2011)Cite this article

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AML in the setting of HIV is rare. Delayed immune reconstitution remains a theoretical risk of treatment. We present a rare case in which auto-SCT was used for consolidation, complicated by autoimmune thrombocytopenia managed by thrombopoietic growth factors.

A 58-year-old man with HIV presented with pancytopenia. BM biopsy confirmed AML with monoblastic morphology and trisomy 8 karyotype. Past history was significant for HIV diagnosed 10 years earlier, managed with antiretrovirals, etravirine 200 mg twice daily and the combination abacavir 300 mg/lamivudine 600 mg daily. At the time of AML diagnosis, HIV-1 RNA load was <40 copies/mL, with a CD4 count of 390 × 106/L and CD4/CD8 ratio of 0.51. The patient also had a history of hepatitis C and had failed IFN and ribavirin treatment 5 years earlier, with a viral load of 1 × 107 IU/mL at the time of AML diagnosis.

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  1. Department of Haematology, Royal Perth Hospital, Perth, Western Australia, Australia

    S A Gangatharan & J P Cooney

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  1. S A Gangatharan
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  2. J P Cooney
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Correspondence to S A Gangatharan.

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Gangatharan, S., Cooney, J. Persistent thrombocytopenia post auto-SCT for AML treated with romiplostim in a patient with HIV. Bone Marrow Transplant 46, 1280–1281 (2011). https://doi.org/10.1038/bmt.2010.298

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