Abstract
We report two cases of severe alloimmune hemolysis after hematopoietic stem cell (HSC) transplant resulting from an anti-Jka. The time course of hemolysis and Jk phenotypes of the donor and recipient in the cases reported suggest that the antibody was produced by donor-derived passenger lymphocytes. Retrospective analysis of the blood bank records of all allogeneic HSC transplant patients at Barnes-Jewish Hospital from 1994 to 1999 suggests that the incidence of alloimmune hemolysis due to incompatibilities involving non-ABO or RhD red cell antigens is very low, approximately 1%. In one patient, the duration of hemolysis was shortened significantly by performing red cell exchange at the first sign of intravascular hemolysis. Bone Marrow Transplantation (2001) 27, 1305–1310.
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The authors are grateful to Drs Lublin and Lorenz for the careful review of this manuscript and the many helpful suggestions.
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Young, P., Goodnough, L., Westervelt, P. et al. Immune hemolysis involving non-ABO/RhD alloantibodies following hematopoietic stem cell transplantation. Bone Marrow Transplant 27, 1305–1310 (2001). https://doi.org/10.1038/sj.bmt.1703074
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DOI: https://doi.org/10.1038/sj.bmt.1703074
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