Genetics and Genomics in 2017

Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer

• Higinio Dopeso
• Paulo Rodrigues
• Diego Arango

Global metabolomic profiling of uterine leiomyomas

• Hanna-Riikka Heinonen
• Miika Mehine
• Eevi Kaasinen

Towards gene- and gender-based risk estimates in Lynch syndrome; age-specific incidences for 13 extra-colorectal cancer types

• Christina Therkildsen
• Steen Ladelund
• Mef Nilbert

Clinically significant mutations in HIV-infected patients with lung adenocarcinoma

• Jonathan Thaler
• Carlie Sigel
• Keith Sigel

Associations of Helicobacter pylori infection and chronic atrophic gastritis with accelerated epigenetic ageing in older adults

• Xu Gao
• Yan Zhang
• Hermann Brenner

Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes

• Javier Gayarre
• Paloma Martín-Gimeno
• María J García

Predicting response to radical (chemo)radiotherapy with circulating HPV DNA in locally advanced head and neck squamous carcinoma

• Jen Y Lee
• Isaac Garcia-Murillas
• Shreerang Bhide

GNAQ and GNA11 mutations and downstream YAP activation in choroidal nevi

• M J C Vader
• M C Madigan
• P A van der Velden

A comparative study of germline BRCA1 and BRCA2 mutation screening methods in use in 20 European clinical diagnostic laboratories

• Gillian Ellison
• Andrew Wallace
• Simon Patton

Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia

• Stephanie A Schubert
• Dina Ruano
• Tom van Wezel

Disseminated tumour cells with highly aberrant genomes are linked to poor prognosis in operable oesophageal adenocarcinoma

• Sarah Schumacher
• Christoph Bartenhagen
• Birte Möhlendick

Whole-genome sequencing revealed novel prognostic biomarkers and promising targets for therapy of ovarian clear cell carcinoma

• Hiroaki Itamochi
• Tetsuro Oishi
• Toru Sugiyama

Clinical study of genomic drivers in pancreatic ductal adenocarcinoma

• Michael T Barrett
• Ray Deiotte
• Daniel D Von Hoff

Non-invasive prediction of recurrence in bladder cancer by detecting somatic TERT promoter mutations in urine

• Françoise Descotes
• Norelyakin Kara
• Alain Ruffion

Comprehensive analysis of copy number aberrations in microsatellite stable colon cancer in view of stromal component

• M Henar Alonso
• Susanna Aussó
• Victor Moreno

Impact of novel miR-145-3p regulatory networks on survival in patients with castration-resistant prostate cancer

• Yusuke Goto
• Akira Kurozumi
• Naohiko Seki

Evaluation of serum microRNA biomarkers for gastric cancer based on blood and tissue pools profiling: the importance of miR-21 and miR-331

• Marek Sierzega
• Marcin Kaczor
• Piotr Richter

Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia

• Maribel Forero-Castro
• Cristina Robledo
• Jesús-María Hernández-Rivas

Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells

• Jenni Nikkilä
• Rahul Kumar
• Christopher J Lord

A meta-analysis of CXCL12 expression for cancer prognosis

• Harsh Samarendra
• Keaton Jones
• Alex Gordon-Weeks