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By taking a neuroanatomy-led gene-therapy approach, AviadoBio is developing targeted drugs and delivery technologies to advance the treatment of neurological conditions such as frontotemporal dementia and amyotrophic lateral sclerosis.
With its first-in-class Cholesterol Degrading Platform (CDP), Repair Biotechnologiesis tackling the root cause of many difficult-to-treat age-related diseases.
NIBEC (the Nano Intelligent Biomedical Engineering Corporation)’s transformative carrier platform is delivering macromolecular drugs to cell and tissue targets throughout the body with improved therapeutic efficacy and reduced side effects.
Deciduous Therapeutics is developing a novel class of immuno-therapies designed to systemically clear senescent cells and to treat co-morbidities of aging.
Achelois BioPharma has built a screening platform to discover T cell-intrinsic genetic-enhancing modifiers that enable tumor-specific T cells to eliminate established tumors in preclinical models and patients.
High-value cell therapy deals are driving investment in the cell and gene therapy field, but new approaches such as gene editing are also beginning to contribute.
Acumen Pharmaceuticals is developing ACU193 as the first clinical-stage therapeutic to selectively target toxic soluble amyloid-β oligomers (AβOs), which are an early and persistent driver of Alzheimer’s disease-related neurodegeneration.
Companies that have pioneered platforms based on oligonucleotides targeting RNA and their biopharma partners continue to move beyond rare diseases into broader patient populations with cardiovascular diseases and central nervous system disorders.
Unique proteolipid vehicle (PLV) technology developed by Entos Pharmaceuticals is broadening the scope for biopharma to deliver nucleic-acid payoffs to target cells throughout the body, paving the way for a new generation of curative drugs.
Genialis is the RNA biomarker company; it espouses a people-first approach to machine learning–driven biomarker discovery. For targeted therapies to benefit the most patients possible, Genialis develops predictive biomarkers to guide treatment decisions. The company’s next-generation biomarkers work for real patients by informing targeted treatment decisions for better outcomes.
Philadelphia’s Aro Biotherapeutics has developed a novel RNA platform that leverages Centyrin proteins to deliver oligonucleotides to muscle and immune cells.
Primrose Bio’s advanced technology for manufacturing nucleic acids and proteins makes it the partner of choice for pharma companies developing new vaccines, therapeutics and bio-based products.
Through its innovative asymmetric siRNA platforms, OliX Pharmaceuticals is opening up huge opportunities in RNA interference-therapeutic development to address unmet needs for various indications spanning the liver, eye, skin, and beyond.
Azor Biotek is applying artificial intelligence solutions to the design and development of tailored, highly specific, novel small molecules, tapping into the vast potential of RNA drug targets.
Cancer Research Horizons (CRH) is harnessing the skills, expertise, and research network of its parent organization to speed-up the discovery and development of transformative oncology drugs, improve patient outcomes, and advance assets for biopharma partners.
Visionary investment in mRNA technology platforms is allowing ST PHARM and its two startups, Levatio Therapeutics and Vernagen, to foster partnerships and advance the development of cutting-edge RNA-based drugs and vaccines.
NurExone has created ExoTherapy, a cutting-edge exosome-based drug-delivery platform, and is currently developing its lead product, ExoPTEN, as a novel therapy for acute spinal cord injuries.