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By supporting research, development and licensing behind its portfolio of companies KDDF is translating Korean science into breakthrough oncology treatments.
Medivir is developing tumor-directed nucleotide oral prodrugs to treat cancers with highly unmet medical needs. The company’s lead drug candidate, MIV-818, is a liver cancer targeted prodrug that Medivir is looking to develop alone in the USA and the EU and through partnerships elsewhere.
Scientists at NIAID have developed broadly neutralizing antibodies (bNAbs) with enhanced neutralizing activity against HIV-1. The new antibodies show improved binding with CD4 by interacting with both binding sites and as a result show improved neutralization of various HIV-1 strains.
With its lead candidate, ATH3G10, a first-in-class antibody indicated for large ST-elevation myocardial infarction (STEMI), Athera Biotechnologies is harnessing the process of efferocytosis to treat a range of vascular diseases.
Inotrem is developing novel immunomodulators that target the TREM-1 pathway. The company’s lead compound, nangibotide, is a first-in-class anti-TREM-1 peptide and is currently in phase 2 trials for septic shock.
Noveome Biotherapeutics, Inc. is developing a new class of biologic consisting of the secretome of a novel population of cells derived from the amnion. Presently, the company is looking for partners to drive clinical drug development of its lead product, ST266, in ophthalmological indications.
enGene has developed a proprietary nonviral gene delivery platform and Gene Pill technology to deliver orally administered gene therapies to mucosal tissues, creating new opportunities for treating hard-to-reach tissues across many indications.
NeuroBo Pharmaceuticals has a phase 3-ready drug candidate, NB-01, in development for painful diabetic neuropathy and a number of other indications, as well as an investigational new drug (IND)-ready candidate, NB-02, that targets Alzheimer’s disease and tauopathies.
By harvesting stem cells from umbilical cord blood and differentiating them into natural killer cells, Glycostem has developed oNKord, an affordable off-the-shelf cell therapy product indicated for oncology therapies that is ready to ship worldwide within 48 hours.
Researchers at the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID) developed a new transient gene expression (TGE) bioprocess using a perfusion system that resolves the current fed-batch limitations for influenza vaccine production.
Researchers at NIAID designed disulfide, cavity-filling and other mutations that stabilize the Nipah F glycoprotein in the prefusion conformation and bind prefusion-specific antibodies. These mutations also increase protein expression yields up to 50-fold.
The Irf8 floxed mouse strain can be used to selectively ablate expression of IRF8 in any cell type in which a Cre recombinase gene is activated. This will permit the identification of IRF8-regulated genes and their effects in specific types of developing and mature cells.