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Dental pulp stem cells in regenerative medicine

BDJ volume 224, pages 747750 (11 May 2018) | Download Citation

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Abstract

The mesenchymal stem cells (dental pulp stem cells; DPSC) found inside teeth represent a significant future source of stem cells for regenerative medicine procedures. This review describes the ontogeny of DPSC; the laboratory processing and collection of DPSC; the immuno-cytochemical characterisation of DPSC; the differentiation between adult DPSC and DPSC obtained from exfoliated deciduous teeth (SHED) and their potential use in regenerative medicine procedures in the future both in dental and general medical applications.

Key points

  • Highlights that dental pulp stem cells are mesenchymal stem cells capable of forming bone, nerves and connective tissue.

  • Highlights that dental pulp stem cells have potential applications in dentistry as well as wider implications in regenerative medicine.

  • Suggests that dentists should encourage the collection and storage of dental pulp stem cells by their patients to ensure that these clinically valuable cells are not discarded as medical waste.

  • Highlights that dental pulp stem cells can be collected and cryogenically stored for later use from exfoliated deciduous teeth and healthy extracted adult teeth.

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Affiliations

  1. WideCells Institute of Stem Cell Technology (ISCT), University of Manchester Innovation Centre, Core Technology Facility, 46 Grafton Street, Manchester, M13 9NT

    • P. Hollands
    • , D. Aboyeji
    •  & M. Orcharton

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Correspondence to P. Hollands.

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DOI

https://doi.org/10.1038/sj.bdj.2018.348