A selection of abstracts of clinically relevant papers from other journals. The abstracts on this page have been chosen and edited by John R. Radford.
Abstract
'Vascular risks of high-dose diclofenac, and possibly ibuprofen'.
Main
Diclofenac moderates inflammatory or post-operative pain (Dental Prescribing App, SDCEP). This paper highlights the risks, albeit small, associated with diclofenac. This advice is grounded on one meta-analysis of 280 trials and one of 474 trials. The average trial duration was less than one year. Diclofenac causes 'around three additional major vascular events per 1,000 participants per year, with one such event causing death'. There are even concerns with the use of diclofenac for those patients with an increased risk of vascular disease. This study also confirms that diclofenac is associated with gastrointestinal events. All these risks were reported with doses of 150 mg daily, as recommended for dental pain. Of note 'Naproxen 500 mg twice a day did not seem to increase the risk of major vascular events'.
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Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Br Dent J 215, 289 (2013). https://doi.org/10.1038/sj.bdj.2013.908
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DOI: https://doi.org/10.1038/sj.bdj.2013.908
