A selection of abstracts of clinically relevant papers from other journals. The abstracts on this page have been chosen and edited by John R. Radford.
Abstract
Ozone offers 'a promising...therapeutic option'.
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Ripamonti CI, Maniezzo M et al. J Bone Oncol 2012; 1: 81–87
Those taking bisphosphonates and other agents that inhibit osteoclast activity such as denosumab (human monoclonal antibody), are at increased risk of osteonecrosis of the jaws (ONJ). The investigators used a Simon two-stage optimal design study to ascertain if ozone therapy 'warrant (s) more extensive development'. It was argued that it was not possible to carry out a RCT. The ozone was delivered topically to the ONJ lesion by circulating the gas in a space created in an impression recorded of the jaw. Twenty-four patient were recruited to the study and all ONJ lesions were >2.5 cm in dimension. Favorable outcomes were reported, with 1) 6 patients exfoliating a sequestrum, 2) when surgical intervention was indicated, a 'healthy mandible edge' was noted, and 3) in none of the patients was there relapse.
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Efficacy and tolerability of medical ozone gas insufflations in patients with osteonecrosis of the jaw treated with bisphosphonates – preliminary data. Br Dent J 214, 349 (2013). https://doi.org/10.1038/sj.bdj.2013.347
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DOI: https://doi.org/10.1038/sj.bdj.2013.347