A selection of abstracts of clinically relevant papers from other journals. The abstracts on this page have been chosen and edited by John R. Radford.
Abstract
No evidence as to the protective effect of NSAIDs in head and neck cancer.
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Wilson JC, Anderson LA et al. Cancer Causes Control 2011; 22: 803–810
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) which in turn may have an anti-tumour effect, particularly for colorectal cancer. In this systematic review examining the effect of NSAIDs on head and neck cancer, over 9,000 articles were identified. No randomised control studies were found. Of the few studies that met the selective criteria, no protective association was found with two drug dispensing studies and no protective association with two case-control studies. However, in the remaining case-control study, there was a significant protective association with low-dose aspirin NSAID. This should be balanced with the findings in another study that reported there was a significantly increased risk of oropharyngeal cancer in those taking non-low-dose aspirin.
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Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer: a systematic review. Br Dent J 212, 129 (2012). https://doi.org/10.1038/sj.bdj.2012.95
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DOI: https://doi.org/10.1038/sj.bdj.2012.95
