A selection of abstracts of clinically relevant papers from other journals. The abstracts on this page have been chosen and edited by John R. Radford.
Abstract
It would appear that clonidine has few advantages compared with adrenaline in local anaesthetic solutions.
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Patil P M, Patil S P. J Oral Maxillofac Surg 2012; 70: 257–262
Local analgesic agents containing adrenaline (epinephrine) should be 'limited or avoided' in ASA Class III and Class IV patients. The aim of this study was to compare the analgesic and therapeutic properties of lidocaine/clonidine to lidocaine/adrenaline. Clonidine is a central antihypertensive drug. In a double blind study, 25 patients received 2% lidocaine with clonidine (15 μg/mL), and 25 patients received 2% lidocaine with epinephrine (12.5 μg/mL) for extraction of upper third molar teeth. All patients were taking antihypertensive medication. Taken in the round, there were few differences between the analgesic efficacy and haemodynamic properties of the two solutions. The investigators carried out a post hoc power calculation. They concede that they should have recruited at least 94 patients to show a possible 'difference of 10 mm Hg between the treatment groups.'
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Is clonidine an adequate alternative to epinephrine as a vasoconstrictor in patients with hypertension?. Br Dent J 212, 491 (2012). https://doi.org/10.1038/sj.bdj.2012.439
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DOI: https://doi.org/10.1038/sj.bdj.2012.439
