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Garavello W, Spreafico R et al. Oral Oncol 2007; 43: 894–897

Studies have reported different conclusions on SCC prognosis in young subjects. The present study was limited to all patients with tongue SCC, without multiple sites or metastasis and with no previous treatment in an Italian medical school from 1981 to 1998. There were 46 aged 40 yrs or less (young) and 92 aged >40 yrs (old).

After treatment, local recurrence affected 39% young and 24% old patients, regional recurrence respectively 26% and 25%, and distant metastasis, 9% and 2%. At 5 yrs, disease-free survival was respectively 34% and 58%, and respective deaths were 50% and 34%. Survival was significantly less for young patients.