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Stecksén-Blicks C, Renfors G et al. Caries Res 2007; 41: 455–459

Early enamel demineralisation adjacent to orthodontic brackets is frequent, and may affect the aesthetic result. This double-masked study randomly allocated 273 children of mean age 14.3 yrs and requiring a maxillary fixed appliance to active fluoride varnish application or placebo varnish. Varnish was applied at bonding and then at every visit (approximately 6 weekly).

At baseline, WSLs were present in 4.3% of the active group and 4.0% of the placebo group (NS), and at debonding, respectively in 11.7% and 29.7% (P <0.001). General absolute risk reduction (ARR) was therefore 18%, and the number needed to treat was 5.6 (NNT: reciprocal of ARR). The incidence of WSLs was reduced in incisors, canines and premolars. The authors recommend adoption of the varnish routinely in such patients.