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Linking immune modulation to cardiac fibrosis

Nature Cardiovascular Research volume 3, pages 414–419 (2024)Cite this article

On 21–23 September 2023, the Immuno-Cardiology Symposium was hosted by the Leducq Foundation Networks of Excellence Program (The Inflammatory-Fibrosis Axis in Adverse LV Remodeling: translating mechanisms into new diagnostics and therapeutics) at The Jackson Laboratory in Bar Harbor, Maine. The symposium highlighted recent advances in the basic science of dysregulated immune system activation and fibrosis in response to cardiac injury.

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Fig. 1
Fig. 2: Central themes that will shape the field of immuno-cardiology in coming years.

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Acknowledgements

The authors are part of the Immuno-Fib HF network. We are indebted to Immuno-Cardiology Symposium participants for their presentations and discussions and apologize to authors whose work we have not cited due to space restrictions. We thank M. Hoelscher for the photograph of the meeting attendees. We thank the contributions from the Jackson Laboratory, M. Hoelscher and L. Detering for the workshop arrangements. The symposium was supported by the Leducq Foundation, Washington University School of Medicine, University of Pennsylvania Perelman School of Medicine, Heidelberg University Hospital, RWTH Aachen University, Hannover Medical School, the International Society for Heart Research: North American Section, Amgen, Kiniksa, Vizgen, Novo Nordisk and SOFIE.

Author information

Authors and Affiliations

  1. Hannover Medical School, Hannover, Germany

    Frank Bengel

  2. University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    Jonathan A. Epstein

  3. Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA

    Robert Gropler & Yongjian Liu

  4. Heidelberg University Hospital, Heidelberg, Germany

    Uwe Haberkorn

  5. Department of Medicine 2, RWTH Aachen University, Medical Faculty, Aachen, Germany

    Rafael Kramann

  6. Center for Cardiovascular Research, Department of Medicine, Cardiovascular Division, Washington University School of Medicine, St Louis, MO, USA

    Kory Lavine

  7. Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA

    Kory Lavine

  8. Department of Developmental Biology, Washington University School of Medicine, St Louis, MO, USA

    Kory Lavine

  9. Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, Heidelberg, Germany

    Florian Leuschner

  10. DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

    Florian Leuschner

  11. The Jackson Laboratory, Bar Harbor, ME, USA

    Nadia Rosenthal

  12. National Heart and Lung Institute, Imperial College London, London, UK

    Nadia Rosenthal

  13. University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

    Hao Wu

Authors
  1. Frank Bengel
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  7. Florian Leuschner
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  8. Yongjian Liu
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  9. Nadia Rosenthal
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  10. Hao Wu
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Corresponding authors

Correspondence to Robert Gropler, Florian Leuschner or Nadia Rosenthal.

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Competing interests

J.A.E. holds equity in Capstan Therapeutics, a biotechnology company focused on developing mRNA approaches to generate CAR-T cells in vivo. R.K. is the founder and shareholder of Sequantrix GmbH and has grants from Travere Therapeutics, Galapagos, Chugai, AskBio and Novo Nordisk, and is a consultant for Bayer, Pfizer, Novo Nordisk, Hybridize Therapeutics and Gruenenthal. U.H. is one of the inventors of a pending patent application (PCT/EP2019/052952) filed by Universität Heidelberg for quinoline-based FAP-targeting agents for imaging and therapy in nuclear medicine, and the description of the radiopharmaceuticals for use in the diagnosis or treatment of a disease characterized by overexpression of FAP in this manuscript is related to this patent application. U.H. holds shares of a consultancy group for iTheranostics. Y.L., R.G. and K.L. are inventors on a pending patent application (US17/001,857) filed by Washington University, and methods for detecting CCR2 receptor described in this manuscript are related to this patent application. Other authors declare no competing interests.

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Bengel, F., Epstein, J.A., Gropler, R. et al. Linking immune modulation to cardiac fibrosis. Nat Cardiovasc Res 3, 414–419 (2024). https://doi.org/10.1038/s44161-024-00459-3

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