Acute depletion of meningeal lymphatic vessels impairs the clearance of cerebrospinal fluid and brain macromolecules. A new study by Antila et al. shows that amyloid pathology in Alzheimer’s disease is neither improved nor aggravated by genetic expansion or depletion of meningeal lymphatic vessels.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Golde, T. E. & Levey, A. I. Science 382, 1242–1244 (2023).
Nauen, D. W. & Troncoso, J. C. Alzheimers Dement 18, 205–210 (2022).
De Leon, M. J. et al. J. Nucl. Med. 58, 1471–1476 (2017).
Antila, S. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-024-00445-9 (2024).
Da Mesquita, S. et al. Nature 560, 185–191 (2018).
Da Mesquita, S. et al. Nature 593, 255–260 (2021).
Oxana, S.-G. et al. Front. Optoelectron. 16, 22 (2023).
Wang, L. et al. Brain Pathol 29, 176–192 (2019).
Matrongolo, M. J. et al. J. Clin. Invest. (2023).
Yoon, J.-H. et al. Nature (2024).
Agarwal, N. et al. J. Magn. Reson. Imaging (2023).
Choi, C. et al. J. Pathol. 255, 296–310 (2021).
Wen, Y.-R. et al. Neural Regen. Res. 13, 709 (2018).
Patel, T. K. et al. Mol. Neurodegener. 14, 11 (2019).
Ding, X.-B. et al. Nat. Med. 27, 411–418 (2021).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Santisteban, M.M., Iadecola, C. A deeper dive into amyloid clearance by meningeal lymphatic vessels. Nat Cardiovasc Res 3, 407–409 (2024). https://doi.org/10.1038/s44161-024-00427-x
Published:
Issue Date:
DOI: https://doi.org/10.1038/s44161-024-00427-x
