Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Biomarkers

Challenges and opportunities for biomarker discovery to predict imminent myocardial infarction

Nature Cardiovascular Research volume 3, pages 102–103 (2024)Cite this article

Subjects

In coronary artery disease, the transition from an apparently stable state to a life-threatening acute cardiac event is difficult to predict. As such, a recent study applied proteomic and metabolomic approaches to discover new biomarkers that signal imminent myocardial infarction.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Ross, R. N. Engl. J. Med. 340, 115–126 (1999).

    Article  CAS  PubMed  Google Scholar 

  2. Gustafsson, S. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-024-00422-2 (2024).

    Article  Google Scholar 

  3. Lowry, M. T. H. et al. Eur. Heart. J. 44, 2846–2858 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Di Angelantonio, E. et al. Circulation 120, 2177–2187 (2009).

    Article  PubMed  Google Scholar 

  5. de Bakker, M. et al. Circulation 147, 1798–1808 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Gürgöze, M. T. et al. Eur. Heart J. Acute Cardiovasc. Care 12, 451–461 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  7. West, N. E. J. et al. JACC Basic Transl. Sci. 2, 646–654 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  8. American Diabetes Association. Diabetes Care 46, S111–S127 (2023).

    Article  Google Scholar 

  9. Parolo, C. et al. ACS Sens. 5, 1877–1881 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Welsh, P. et al. Clin. Chem. https://doi.org/10.1093/clinchem/hvad205 (2023).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

D.M.K. is supported by a British Heart Foundation Intermediate Basic Science Research Fellowship (FS/IBSRF/23/25161). N.L.M. is supported by a Chair Award (CH/F/21/90010), Programme Grant (RG/20/10/34966) and a Research Excellent Award (RE/18/5/34216) from the British Heart Foundation.

Author information

Authors and Affiliations

  1. BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK

    Marie de Bakker, Dorien M. Kimenai & Nicholas L. Mills

  2. Usher Institute, University of Edinburgh, Edinburgh, UK

    Nicholas L. Mills

Authors
  1. Marie de Bakker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dorien M. Kimenai
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nicholas L. Mills
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nicholas L. Mills.

Ethics declarations

Competing interests

N.L.M. reports receiving research grants awarded to the University of Edinburgh from Abbott Diagnostics, Siemens Healthineers and Roche Diagnostics unrelated to this work, and honoraria from Abbott Diagnostics, Siemens Healthineers, Roche Diagnostics, LumiraDx and Psyros Diagnostics.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

de Bakker, M., Kimenai, D.M. & Mills, N.L. Challenges and opportunities for biomarker discovery to predict imminent myocardial infarction. Nat Cardiovasc Res 3, 102–103 (2024). https://doi.org/10.1038/s44161-024-00424-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44161-024-00424-0

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing