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Cardiac repair

Cardioprotective effects of the angiocrine CRELD2 after ischemic injury

Nature Cardiovascular Research volume 3, pages 104–105 (2024)Cite this article

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In acute myocardial infarction treated with reperfusion, functional preservation of myocardium requires an angiogenic response. A new study shows that CRELD2, an endoplasmic reticulum (ER)-resident protein induced in response to ER stress, acts as an angiocrine factor to limit cardiac dysfunction after ischemia/reperfusion injury in mice.

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Fig. 1: Approaches to limit the progression of heart failure due to ischemia.

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA

    Lauren E. Parker & Ravi Karra

  2. Department of Pathology, Duke University Medical Center, Durham, NC, USA

    Ravi Karra

Authors
  1. Lauren E. Parker
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  2. Ravi Karra
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Correspondence to Ravi Karra.

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The authors declare no competing interests.

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Parker, L.E., Karra, R. Cardioprotective effects of the angiocrine CRELD2 after ischemic injury. Nat Cardiovasc Res 3, 104–105 (2024). https://doi.org/10.1038/s44161-023-00415-7

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