Clonal hematopoiesis of indeterminate potential (CHIP) is a risk factor for cardiovascular disease. Neutralization of the cytokine IL-1β (as in the CANTOS clinical trial) resulted in a greater reduction in adverse cardiovascular events in patients with CHIP than the reduction in molecularly unstratified patients. New research reveals that some of the cardiovascular benefits of anti-IL-1β therapy in patients with CHIP might be delivered by an improvement in plaque stability via increased fibroblast-like cells.
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X.L. is an inventor on the UK patent ‘Treatment of Inflammatory Diseases’ (application no. 2313514.8). M.C.H.C. declares no competing interests.
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Li, X., Clarke, M.C.H. Expansion of fibroblast-like cells may explain the CANTOS meta-analysis findings for patients with clonal hematopoiesis. Nat Cardiovasc Res 3, 23–25 (2024). https://doi.org/10.1038/s44161-023-00409-5
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DOI: https://doi.org/10.1038/s44161-023-00409-5