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Atherosclerosis

Unveiling novel genetic insights into arterial calcification

Coronary artery calcification (CAC) is a strong predictor of coronary artery disease. A genome-wide association study of CAC in diverse populations, including 22,400 participants, identifies two previously unrecognized loci associated with CAC and provides insights into the underlying molecular mechanism of CAC.

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Fig. 1: The genetics of CAC.

References

  1. Hutcheson, J. D. & Goettsch, C. Circ. Res. 132, 993–1012 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Drobni, Z. D. et al. Circ. Cardiovasc. Imaging 15, e013348 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Natarajan, P. et al. Circ. Cardiovasc. Genet. 9, 511–520 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Wojczynski, M. K. et al. BMC Med. Genet. 14, 75 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Kavousi, M. et al. Nat. Genet. 55, 1651–1664 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Sun, L. et al. Am. J. Hum. Genet. 110, 903–912 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. de Vries, P. S. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-023-00375-y (2023).

    Article  Google Scholar 

  8. Erqou, S. et al. Neth. Heart J. 23, 44–51 (2015).

    Article  CAS  PubMed  Google Scholar 

  9. Brunetti-Pierri, N. et al. Am. J. Med. Genet. A 117A, 164–168 (2003).

    Article  PubMed  Google Scholar 

  10. Matos-Miranda, C. et al. Genet. Med. 15, 650–657 (2013).

    Article  CAS  PubMed  Google Scholar 

  11. Franco, B. et al. Cell 81, 15–25 (1995).

    Article  CAS  PubMed  Google Scholar 

Download references

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Correspondence to Claudia Goettsch.

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Goettsch, C. Unveiling novel genetic insights into arterial calcification. Nat Cardiovasc Res 2, 1102–1103 (2023). https://doi.org/10.1038/s44161-023-00379-8

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