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Megakaryopoiesis and platelets

Lipid remodeling in megakaryocyte differentiation and platelet biogenesis

Nature Cardiovascular Research volume 2, pages 803–804 (2023)Cite this article

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Lipid remodeling, from fatty acid transport and de novo lipid synthesis, is necessary for megakaryocyte differentiation and platelet production. Dietary saturated fatty acids, impaired fatty acid transport and/or dysfunction in lipid biogenesis can contribute to low platelet counts.

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Fig. 1: Lipid reprogramming during MK differentiation and maturation drives platelet production and phenotype.

References

  1. Capolupo, L. Nat. Rev. Mol. Cell Biol. 24, 377 (2023).

    Article  CAS  PubMed  Google Scholar 

  2. Capolupo, L. et al. Science 376, eabh1623 (2022).

    Article  CAS  PubMed  Google Scholar 

  3. Valet, C. et al. Cell Rep. 32, 107875 (2020).

    Article  CAS  PubMed  Google Scholar 

  4. Kelly, K. L. et al. Nat. Metab. 2, 1163–1178 (2020).

    Article  CAS  PubMed  Google Scholar 

  5. de Jonckheere, B. et al. Nat. Cardiovasc. Res. https://doi.org/s44161-023-00325-8 (2023).

  6. Barrachina, M. N. et al. Nat. Cardiovasc. Res. 2, 746–763 (2023).

    Article  Google Scholar 

  7. Chicanne, G. et al. Platelets 34, 2182180 (2023).

    Article  PubMed  Google Scholar 

  8. Slatter, D. A. et al. Cell Metab. 23, 930–944 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. So, J. S. et al. Cell Metab. 16, 487–499 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Jain, K. et al. Circ. Res. 131, 290–307 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Gaertner, F. & Massberg, S. Nat. Rev. Immunol. 19, 747–760 (2019).

    Article  CAS  PubMed  Google Scholar 

  12. Tyagi, T. et al. J. Exp. Med. 220, e20212218 (2023).

    Article  CAS  PubMed  Google Scholar 

  13. Chen, Y., Zhang, J., Cui, W. & Silverstein, R. L. J. Exp. Med. 219, e20211314 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This work was funded in part by the US National Institutes of Health (R01-HL122815, R01-HL150515 and U54-DK106857) to J.H. and by an American Heart Association Career Development Award (23CDA1054296) to K.J.

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  1. These authors contributed equally: Kanika Jain, Tarun Tyagi.

Authors and Affiliations

  1. Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA

    Kanika Jain, Tarun Tyagi & John Hwa

  2. Yale Cooperative Center of Excellence in Hematology, Yale University School of Medicine, New Haven, CT, USA

    John Hwa

Authors
  1. Kanika Jain
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  2. Tarun Tyagi
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  3. John Hwa
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Correspondence to John Hwa.

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Jain, K., Tyagi, T. & Hwa, J. Lipid remodeling in megakaryocyte differentiation and platelet biogenesis. Nat Cardiovasc Res 2, 803–804 (2023). https://doi.org/10.1038/s44161-023-00324-9

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