We established a mouse model that recapitulates the clinical symptoms of Takotsubo syndrome (‘broken heart syndrome’) and revealed a causal relationship between calcineurin-dependent cardiac inflammation and disease severity. Inhibition of calcineurin as a therapeutic approach is now entering a multi-center clinical trial.
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References
Singh, T. et al. Takotsubo syndrome: pathophysiology, emerging concepts, and clinical implications. Circulation 145, 1002–1019 (2022). A review article on TTS that presents epidemiological data and the unmet medical need.
Omerovic, E. et al. Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 1: overview and the central role for catecholamines and sympathetic nervous system. Eur. J. Heart Fail. 24, 257–273 (2022). A joint scientific statement that highlights our current understanding of catecholamine signaling in TTS.
Weinreuter, M. et al. CaM kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury. EMBO Mol. Med. 6, 1231–1245 (2014). This paper reports that calcium-dependent mechanisms initiate myocardial inflammation in cardiomyocytes.
Scally, C. et al. Myocardial and systemic inflammation in acute stress-induced (Takotsubo) cardiomyopathy. Circulation 139, 1581–592 (2019). This paper reports that TTS is characterized by myocardial and systemic inflammation.
Cammann, V. L. et al. Clinical features and outcomes of patients with malignancy and takotsubo syndrome: observations from the international Takotsubo registry. J. Am. Heart Assoc. 8, e010881 (2019). This paper shows the coexistence of TTS with cancer in a large TTS registry.
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This is a summary of: Bruns, B. et al. Calcineurin signaling promotes takotsubo syndrome. Nat. Cardiovas. Res. https://doi.org/10.1038/s44161-023-00296-w (2023).
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Mechanistic insights into the ‘broken heart syndrome’. Nat Cardiovasc Res 2, 613–614 (2023). https://doi.org/10.1038/s44161-023-00309-8
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DOI: https://doi.org/10.1038/s44161-023-00309-8
