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Hijacking CD177 for whole-body visualization of neutrophil dynamics

Nature Cardiovascular Research volume 2, pages 104–105 (2023)Cite this article

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Tissue infiltration of neutrophils is a key event of sterile and pathogen-induced inflammation; however, there is at present no non-invasive tool to visualize neutrophil dynamics in the body. Bouvain et al. develop a neutrophil-specific tracer that enables longitudinal imaging of neutrophil flux across the whole body.

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Fig. 1: CD177-tagging enables visualization of neutrophil flux.

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Acknowledgements

O.S. receives funding from the Deutsche Forschungsgemeinschaft (TRR332 A2 & Z1, CRC1123 A6, CRC1009 A13, CRC914 B8, OR465/1-1), the IZKF of the Medical Faculty at the University of Münster, Novo Nordisk, and the Leducq foundation.

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  1. Institute of Experimental Pathology (ExPat), Centre of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany

    Oliver Soehnlein

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  1. Oliver Soehnlein
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Correspondence to Oliver Soehnlein.

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Competing interests

O.S. receives support from Novo Nordisk to circadian rhythms in atherosclerosis and to target histones H4 in inflammation; O.S. holds patents on histone neutralization and interference with chemokine heteromers.

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Soehnlein, O. Hijacking CD177 for whole-body visualization of neutrophil dynamics. Nat Cardiovasc Res 2, 104–105 (2023). https://doi.org/10.1038/s44161-022-00211-9

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