GPR55 is a G protein–coupled receptor that is activated by endogenous lipid mediators. Our findings in experimental mouse models of atherosclerosis and human plaques indicate that GRP55 signaling is important for limiting B cell activation and humoral responses during hypercholesterolemia, which suggests that GPR55 signaling has an atheroprotective role.
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This is a summary of: Guillamat-Prats, R. et al. GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00155-0 (2022).
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A lipid-binding receptor reduces B cell activation in early atherosclerosis. Nat Cardiovasc Res 1, 984–985 (2022). https://doi.org/10.1038/s44161-022-00169-8
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DOI: https://doi.org/10.1038/s44161-022-00169-8
