The rapid enhancement of cardiac Ca2+ current (ICa,L) is central to enhanced heart function during the sympathetic fight-or-flight response. A new study shows how the small GTPase Rad mediates tonic ICa,L inhibition that is relieved after PKA-dependent phosphorylation of Rad, which causes release of Rad from the Ca2+ channel and increased ICa,L.
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References
Bers, D. M. et al. Physiology (Bethesda) 34, 240–249 (2019).
Liu, G. et al. Nature 577, 695–700 (2020).
Papa, A. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00157-y (2022).
Manning, J. R. et al. J. Am. Heart Assoc. 2, e000459 (2013).
Negroni, J. A. et al. J. Mol. Cell Cardiol. 81, 162–175 (2015).
Reuter, H. J. Physiol. (Lond.) 192, 479–492 (1967).
De Jongh, K. S. et al. Biochemistry 35, 10392–103402 (1996).
Gao, T. et al. Neuron 19, 185–196 (1997).
Lemke, T. et al. J. Biol. Chem. 283, 34738–34744 (2008).
Finlin, B. S. et al. Proc. Natl Acad. Sci. USA 100, 14469–14474 (2003).
Qian, H. et al. Sci. Signal. 10, eaaf9659 (2017).
Nystoriak, M. A. et al. Sci. Signal. 10, eaaf9647 (2017).
Papa, A. et al. Annu. Rev. Physiol. 84, 285–306 (2022).
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Bers, D.M. Cardiac Ca2+ current is ‘Rad’-ically altered by adrenergic activation. Nat Cardiovasc Res 1, 980–981 (2022). https://doi.org/10.1038/s44161-022-00163-0
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DOI: https://doi.org/10.1038/s44161-022-00163-0
