Blood vascular leakage in conjunction with stroke causes edema and a worsened outcome. Through augmented and selective tyrosine phosphatase activity, endothelial junctions can be sealed, resulting in reduced stroke volume and improved survival.
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The authors acknowledge support from the Swedish Cancer foundation and the Knut and Alice Wallenberg foundation.
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Richards, M., Claesson-Welsh, L. Targeting VEGF-induced vascular permeability. Nat Cardiovasc Res 1, 413–414 (2022). https://doi.org/10.1038/s44161-022-00066-0
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DOI: https://doi.org/10.1038/s44161-022-00066-0